PMID: 7010182Mar 19, 1981Paper

Structure of the neuraminidase gene in human influenza virus A/PR/8/34

Nature
S FieldsG G Brownlee

Abstract

The complete structure of the neuraminidase gene in influenza A/PR/8/34 has been determined by cloning into the bacteriophage M13 and sequencing with dideoxynucleotide chain terminators. The gene is 1,413 nucleotides long, codes for a protein of 454 amino acids and has five potential glycosylation sites. We suggest that the neuraminidase, unlike the influenza haemagglutinin, is oriented with its N-terminus buried in the viral membrane.

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