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Structure of the neurotensin receptor 1 in complex with β-arrestin 1

Nature

Jan 17, 2020

Weijiao HuangBrian K Kobilka

Abstract

Arrestin proteins bind to active, phosphorylated G-protein-coupled receptors (GPCRs), thereby preventing G-protein coupling, triggering receptor internalization, and affecting various downstream signalling pathways1,2. Although there is a wealth of structural information delineating the...read more

Mentioned in this Paper

RHO
G-Protein-Coupled Receptors
Phosphatidylinositol 4,5-Diphosphate
Neurotensin type 1 receptor
Heterotrimeric G-protein Binding
Beta-arrestin
Protein Phosphorylation
SAG
Downstream
Activation of Receptor Internalization
74
2
3
Paper Details
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Structure of the neurotensin receptor 1 in complex with β-arrestin 1

Nature

Jan 17, 2020

Weijiao HuangBrian K Kobilka

PMID: 31945771

DOI: 10.1038/s41586-020-1953-1

Abstract

Arrestin proteins bind to active, phosphorylated G-protein-coupled receptors (GPCRs), thereby preventing G-protein coupling, triggering receptor internalization, and affecting various downstream signalling pathways1,2. Although there is a wealth of structural information delineating the...read more

Mentioned in this Paper

RHO
G-Protein-Coupled Receptors
Phosphatidylinositol 4,5-Diphosphate
Neurotensin type 1 receptor
Heterotrimeric G-protein Binding
Beta-arrestin
Protein Phosphorylation
SAG
Downstream
Activation of Receptor Internalization
74
2
3

Similar Papers Found In These Feeds

Stanford Gastroenterology & Hepatology

Find the latest research from the Gastroenterology and Hepatology Department at Stanford University here.

GPCRs Signaling Pathway

G-protein coupled receptors (GPCRs) are membrane receptors implicated in the pathophysiology of various diseases, including neurodegenerative disorders, infectious diseases, and cancer. Here is the latest research on GPCR signaling pathway.

Related Papers

Cell Research

A complex structure of arrestin-2 bound to a G protein-coupled receptor

Cell ResearchNovember 29, 2019
Wanchao YinH Eric Xu
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