PMID: 8950183Nov 11, 1996Paper

Structure of the rat collagen IV promoter

Biochimica Et Biophysica Acta
J P GrandeE D Wieben

Abstract

We have isolated a 1.6 kb clone from a rat genomic library which contains the bidirectional collagen IV promoter, flanked by exons coding for the alpha 1 (IV) and alpha 2 (IV) collagen chains. There are at least two transcription start sites within both the alpha 1 (IV) and alpha 2 (IV) collagen genes. Rat mesangial cells were transfected with chloramphenicol acetyltransferase (CAT) reporter plasmids containing segments of the promoter and 5' flanking region, in both the alpha 1 (IV) and alpha 2 (IV) orientations. Our results suggest that transcriptional efficiency of the bidirectional promoter is more efficient in the alpha 2 (IV) direction than in the alpha 1 (IV) direction.

References

Jan 1, 1990·Annals of the New York Academy of Sciences·R PollnerK Kühn
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P D BurbeloY Yamada
Feb 1, 1995·Matrix Biology : Journal of the International Society for Matrix Biology·K Kühn

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Citations

Feb 8, 2003·Genomics·Ferrin C NoonanTheodore C Simon
Jun 1, 2005·Biological Reviews of the Cambridge Philosophical Society·Johanson Zerina, Moya M Smith
Oct 6, 1997·Genome Research·J W Fickett, A G Hatzigeorgiou
Feb 22, 2002·Experimental Biology and Medicine·Joseph P GrandeKarl A Nath
Dec 18, 2002·Experimental Biology and Medicine·Jingfei Cheng, Joseph P Grande
Mar 30, 2021·Oxidative Medicine and Cellular Longevity·Nevena GrdovićMirjana Mihailović

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