Structure of the transmembrane region of the M2 protein H(+) channel

Protein Science : a Publication of the Protein Society
J WangT Cross

Abstract

The transmembrane domain of the M2 protein from influenza A virus forms a nearly uniform and ideal helix in a liquid crystalline bilayer environment. The exposure of the hydrophilic backbone structure is minimized through uniform hydrogen bond geometry imposed by the low dielectric lipid environment. A high-resolution structure of the monomer backbone and a detailed description of its orientation with respect to the bilayer were achieved using orientational restraints from solid-state NMR. With this unique information, the tetrameric structure of this H(+) channel is constrained substantially. Features of numerous published models are discussed in light of the experimental structure of the monomer and derived features of the tetrameric bundle.

References

Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G B FieldsT A Cross
Apr 1, 1989·International Journal of Peptide and Protein Research·C G FieldsT A Cross
Aug 30, 1994·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M F Luciani, P Golstein
Oct 1, 1994·Journal of Pharmaceutical Sciences·M H Abraham, P K Weathersby
Mar 11, 1994·Journal of Molecular Biology·N L HarrisF E Cohen
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·S ArumugamT A Cross
Jan 1, 1996·Annual Review of Biophysics and Biomolecular Structure·R E Koeppe, O S Anderson
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·T SakaguchiR A Lamb
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·L H PintoW F DeGrado
Jan 10, 1998·Biochemistry·J F HuntD M Engelman
Sep 22, 1998·FEBS Letters·Q ZhongM L Klein
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·F Xu, T A Cross
Jan 7, 2000·Journal of Molecular Biology·F A KovacsT A Cross
Feb 3, 2000·Nature Structural Biology·F X ZhouD M Engelman
Apr 28, 2000·Journal of Magnetic Resonance·F M Marassi, S J Opella
Apr 28, 2000·Journal of Magnetic Resonance·J WangT A Cross
Dec 2, 2000·Nature Structural Biology·M M Zhou
May 13, 1983·Science·S KirkpatrickM P Vecchi

❮ Previous
Next ❯

Citations

Sep 4, 2009·European Biophysics Journal : EBJ·Gabriel A Cook, Stanley J Opella
Dec 19, 2009·European Biophysics Journal : EBJ·Andrea Holt, J Antoinette Killian
May 14, 2004·Journal of Magnetic Resonance·Sanguk Kim, T A Cross
Apr 18, 2002·Current Opinion in Structural Biology·Benoît Roux
Dec 5, 2002·Current Opinion in Structural Biology·Lynmarie K Thompson
Mar 14, 2003·Trends in Biochemical Sciences·Jaume TorresMontserrat Samsó
Dec 18, 2002·Journal of the American Society for Mass Spectrometry·Raino K HansenIsaiah T Arkin
Mar 28, 2003·Journal of Magnetic Resonance·Francesca M Marassi, Kevin J Crowell
Aug 14, 2003·Journal of Magnetic Resonance·Michael F Mesleh, Stanley J Opella
Aug 14, 2003·Journal of Magnetic Resonance·Richard BertramMichael S Chapman
Aug 23, 2003·Journal of Magnetic Resonance·Sergey V DvinskikhDick Sandström
Jul 16, 2009·Biochemistry·Sarah D CadyMei Hong
Aug 12, 2004·Chemical Reviews·Stanley J Opella, Francesca M Marassi
Nov 17, 2012·Chemical Reviews·Joseph W F RobertsonSoojay Banerjee
Apr 19, 2002·Journal of the American Chemical Society·Michael F MeslehStanley J Opella
Jul 17, 2003·Journal of the American Chemical Society·Michael F MeslehStanley J Opella
Apr 5, 2007·Journal of the American Chemical Society·Conggang LiTimothy A Cross
Aug 12, 2010·Journal of the American Chemical Society·Loren B AndreasRobert G Griffin
Jun 1, 2010·Journal of the American Chemical Society·Robert W KnoxAlexander A Nevzorov
Feb 1, 2008·Nature·Jason R Schnell, James J Chou
Nov 10, 2009·Nature Structural & Molecular Biology·Junfeng WangJames J Chou
Jan 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sarah D Cady, Mei Hong
Jan 16, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ekta KhuranaMichael L Klein
Jul 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Chunlong MaLawrence H Pinto
Jul 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Myunggi YiHuan-Xiang Zhou
May 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ana Carolina ZeriStanley J Opella
Jun 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kathleen P HowardWilliam F DeGrado
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Lidia CristianWilliam F DeGrado
Apr 15, 2008·The Journal of Biological Chemistry·Chunlong MaLawrence H Pinto
Aug 13, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Suzana K Straus
Jan 12, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Jan K RaineyBrian D Sykes
Dec 6, 2011·Annual Review of Physical Chemistry·Mei HongFanghao Hu
Jan 26, 2016·Journal of the American Chemical Society·Anna K WrightTimothy A Cross
Jul 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ruibin LiangGregory A Voth
May 30, 2015·The Journal of General Virology·Claire Scott, Stephen Griffin
Nov 1, 2006·Journal of Magnetic Resonance·Alexander A Nevzorov, Stanley J Opella
Feb 11, 2014·Journal of Magnetic Resonance·D T MurrayT A Cross

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.