Structure of the ubiquitous 3' processing enzyme RNase Z bound to transfer RNA

Nature Structural & Molecular Biology
Inés Li de la Sierra-GallayCiarán Condon

Abstract

The highly conserved ribonuclease RNase Z catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors. Here we present the structure of the complex between Bacillus subtilis RNase Z and tRNA(Thr), the first structure of a ribonucleolytic processing enzyme bound to tRNA. Binding of tRNA to RNase Z causes conformational changes in both partners to promote reorganization of the catalytic site and tRNA cleavage.

References

Mar 1, 1988·Acta Crystallographica. Section A, Foundations of Crystallography·E WesthofD Moras
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·A KunzmannA Marchfelder
Feb 15, 2001·Nature Genetics·S V TavtigianL A Cannon-Albright
Jul 11, 2001·Biochemistry·S SchifferA Marchfelder
Mar 9, 2002·Journal of Molecular Biology·Karina SchierlingAnita Marchfelder
Dec 20, 2002·Nucleic Acids Research·Ciarán Condon, Harald Putzer
Aug 28, 2003·The EMBO Journal·Olivier PellegriniCiarán Condon
Jan 30, 2004·The Journal of Biological Chemistry·Asako MinagawaMasayuki Nashimoto
Jan 18, 2005·Nature·Inés Li de la Sierra-GallayCiarán Condon
Feb 9, 2005·The Journal of Biological Chemistry·Oliver SchillingAndreas Vogel
Feb 11, 2005·The Journal of Biological Chemistry·Ryohei IshiiShigeyuki Yokoyama

❮ Previous
Next ❯

Citations

Dec 26, 2007·Cellular and Molecular Life Sciences : CMLS·C R MandelL Tong
Jul 28, 2007·Biochemistry·Shay KarkashonLouis Levinger
Mar 17, 2007·Nature Reviews. Microbiology·Yulia RedkoCiarán Condon
Jan 22, 2008·Nature Structural & Molecular Biology·Inés Li de la Sierra-GallayHarald Putzer
Sep 15, 2009·Nature Structural & Molecular Biology·Sakurako Goto-ItoShigeyuki Yokoyama
Apr 16, 2009·The Journal of Biological Chemistry·Tanmay Dutta, Murray P Deutscher
Aug 16, 2012·The Journal of Biological Chemistry·Tanmay DuttaMurray P Deutscher
Apr 16, 2009·The Journal of Biological Chemistry·Kateryna PodzelinskaZongchao Jia
Apr 9, 2009·The Journal of Biological Chemistry·Louis LevingerChristopher Wilson
Aug 19, 2006·Nucleic Acids Research·Asako MinagawaMasayuki Nashimoto
Aug 28, 2012·Nucleic Acids Research·Kosuke ItoToshio Uchiumi
Sep 3, 2010·Genes & Development·Eric M Phizicky, Anita K Hopper
Aug 3, 2007·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Ryohei IshiiShigeyuki Yokoyama
May 22, 2009·RNA·Roula Daou-Chabo, Ciarán Condon
Jul 23, 2013·PloS One·Christopher WilsonEmmanuel J Chang
Sep 21, 2010·Journal of Structural Biology·Bijàn Mir-MontazeriMarcus D Hartmann
Jun 21, 2007·Current Opinion in Structural Biology·Hong Li
Jun 15, 2007·Current Opinion in Microbiology·Ciarán Condon
Jan 19, 2007·Molecular Microbiology·Robert A BrittonCiarán Condon
Feb 23, 2010·Environmental and Molecular Mutagenesis·Emma CattellPeter J McHugh
Apr 5, 2016·Biomolecules·Jinwei Zhang, Adrian R Ferré-DAmaré
Apr 3, 2013·Biochimica Et Biophysica Acta·Cecília Maria ArraianoBertrand Séraphin
Dec 6, 2011·Biochimica Et Biophysica Acta·Walter Rossmanith
Dec 27, 2006·Current Opinion in Structural Biology·Jonathan A R Worrall, Ben F Luisi
Sep 4, 2012·Structure·Olivier PellegriniCiarán Condon
Jul 8, 2008·Journal of Molecular Biology·Asako MinagawaMasayuki Nashimoto
Feb 14, 2009·Progress in Molecular Biology and Translational Science·Roland K HartmannAnita Marchfelder
Apr 6, 2017·Nucleic Acids Research·Miao MaHerman van Tilbeurgh
Apr 25, 2007·Critical Reviews in Biochemistry and Molecular Biology·Zbigniew Dominski
Jun 30, 2018·RNA·Jinjie ShangYing Huang
Sep 12, 2013·The Journal of Biological Chemistry·Tanmay DuttaMurray P Deutscher
Apr 24, 2018·FEMS Microbiology Reviews·Béatrice Clouet-d'OrvalLisa-Katharina Maier
Aug 30, 2019·Critical Reviews in Biochemistry and Molecular Biology·David H Bechhofer, Murray P Deutscher
Feb 23, 2020·Cell Reports·Matthew C J YipSichen Shao
Sep 5, 2019·Biochemical and Biophysical Research Communications·Hye-Won NaSung-Il Yoon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.