Structure of the vacuolar adenosine triphosphatases

Cell Biochemistry and Biophysics
S Wilkens

Abstract

Vacuolar adenosine triphosphatases (V-ATPases) represent an important class of proton pumps found in endomembrane systems of eucaryotic cells, where they are involved in pH regulation. Progress has been made in the structure determination of this large, membrane-bound multisubunit enzyme complex. Electron microscopy of the V-ATPase has revealed a ball-and-stalk-like structure similar to F1F0-type ATP synthase, to which the V-ATPase is evolutionary related. Aside from the overall structural similarity of the V-ATPase and F-ATP synthase, a number of distinct structural differences exist between the two related enzymes, giving clues to their different function and regulation in the organism.

Citations

Jul 2, 2003·FEBS Letters·Andrea ArmbrüsterGerhard Grüber
Jan 5, 2005·Micron : the International Research and Review Journal for Microscopy·Stephan WilkensYesha Zheng
Feb 11, 2014·Biochimica Et Biophysica Acta·Vladimir MarshanskyGerhard Grüber
Mar 22, 2014·Biochimica Et Biophysica Acta·Gerhard GrüberVolker Müller
Aug 14, 2003·Biochimica Et Biophysica Acta·Helmut Plattner, Roland Kissmehl
Oct 19, 2005·Advances in Protein Chemistry·Stephan Wilkens
Sep 10, 2003·The Journal of Biological Chemistry·Zhenyu ZhangStephan Wilkens

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