Structure of zebrafish IRBP reveals fatty acid binding

Experimental Eye Research
Debashis GhoshFederico Gonzalez-Fernandez

Abstract

Interphotoreceptor retinoid-binding protein (IRBP) has a remarkable role in targeting and protecting all-trans and 11-cis retinol, and 11-cis retinal during the rod and cone visual cycles. Little is known about how the correct retinoid is efficiently delivered and removed from the correct cell at the required time. It has been proposed that different fatty composition at that the outer-segments and retinal-pigmented epithelium have an important role is regulating the delivery and uptake of the visual cycle retinoids at the cell-interphotoreceptor-matrix interface. Although this suggests intriguing mechanisms for the role of local fatty acids in visual-cycle retinoid trafficking, nothing is known about the structural basis of IRBP-fatty acid interactions. Such regulation may be mediated through IRBP's unusual repeating homologous modules, each containing about 300 amino acids. We have been investigating structure-function relationships of Zebrafish IRBP (zIRBP), which has only two tandem modules (z1 and z2), as a model for the more complex four-module mammalian IRBP's. Here we report the first X-ray crystal structure of a teleost IRBP, and the only structure with a bound ligand. The X-ray structure of z1, determined at 1.90 Å re...Continue Reading

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Citations

May 8, 2016·Experimental Eye Research·Debashis GhoshFederico Gonzalez-Fernandez
Oct 26, 2018·The Biochemical Journal·Anahita DaruwallaPhilip D Kiser
Aug 30, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Avery E SearsKrzysztof Palczewski
Nov 15, 2020·The Journal of Biological Chemistry·Philip D Kiser, Krzysztof Palczewski
Nov 27, 2019·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Made Airanthi K Widjaja-Adhi, Marcin Golczak
Dec 18, 2020·Frontiers in Cellular Neuroscience·Shaoxue ZengLing Zhu
Jan 13, 2021·The Journal of Biological Chemistry·Philip D Kiser, Krzysztof Palczewski

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