Structure, organization, and chromosomal mapping of the gene encoding macrosialin, a macrophage-restricted protein

Genomics
Z JiangMaria C de Beer

Abstract

Murine macrosialin and its human homologue CD68 are heavily glycosylated transmembrane proteins expressed specifically in macrophages and macrophage-related cells. Macrosialin is predominantly a late endosomal protein but is also found on the cell surface where it binds oxidized LDL, an important factor in atherogenesis. We have cloned and sequenced the murine macrosialin gene (Cd68) and localized it by linkage analysis to chromosome 11. The gene is 1908 nucleotides long from the start site of transcription to the end of the 3'UTR. It has six exons, which range in size from 79 to 434 nucleotides. The promoter lacks a classical TATA box but contains other protein binding sites consistent with preferential monocyte/macrophage gene expression. Although the function of macrosialin is unknown, it might play a role in lipoprotein regulation given its binding of oxidized LDL in vitro and its colocalization to a region on chromosome 11 involved in the control of HDL levels.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K S MoultonC K Glass
Jan 1, 1986·Annual Review of Biochemistry·R A PadgettP A Sharp
Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·K F Manly
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·M P RamprasadD Steinberg
Jan 1, 1997·Virchows Archiv : an International Journal of Pathology·S NakatsujiS Sakuma
Mar 6, 1997·Nature·M M TondraviS L Teitelbaum
Aug 22, 1997·The Journal of Biological Chemistry·D Steinberg
Dec 13, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C L WelchA J Lusis

❮ Previous
Next ❯

Citations

Sep 22, 1999·European Journal of Biochemistry·N KurosawaT Muramatsu
Oct 29, 2010·International Journal of Hypertension·Sam L StephenSreenivasan Ponnambalam
Oct 21, 2015·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jennifer T O'MalleyMichael J McKenna
Oct 9, 2007·Methods : a Companion to Methods in Enzymology·Annette PlüddemannSiamon Gordon
Apr 28, 2004·Biochemical and Biophysical Research Communications·Gemma LlaveriasMarta Alegret
Aug 24, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S HankemeierA Probst
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Donna M DambachDebra L Laskin
Nov 22, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Dimitry A ChistiakovYuri V Bobryshev
Feb 4, 2003·Journal of Lipid Research·Maria C de BeerWillem J S de Villiers
Apr 5, 2003·The Journal of Biological Chemistry·Dawn O'ReillyDavid R Greaves
Feb 3, 2004·The Journal of Biological Chemistry·Dominique Sawka-VerhelleChristopher K Glass
Feb 6, 2020·Chonnam Medical Journal·Sunhyo RyuPeter I Song
May 21, 2005·Atherosclerosis·Jane E MurphySreenivasan Ponnambalam
Dec 16, 2021·JAMA Cardiology·Ludwig T WeckbachUNKNOWN EMB Study Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.