Structure-process-functional property relationship of nanostructured carbon mediated cellular response for soft-tissue reconstruction and replacement

Acta Biomaterialia
R D K MisraJ S Shah

Abstract

The flexible and ductile silicone is widely used as a soft-tissue substitute for joint reconstruction and replacement in situations including joint pain and loss of mobility caused by the congenital or acquired factors such as osteoarthritis. Although these artificial devices have an expected life span of 15 years or more, they can fragment prematurely. Explanations for such failure are low tensile strength and inadequate bone build-up around the device, as a result of which the device does not bind with the surrounding tissues. Thus, the continued challenge for materials in contact with the bone is the design of high-strength-at-break silicone with the ability to modulate cell-substrate interactions for promoting osseointegration and long-term stability. To this end, we have discovered exciting evidence that the introduction of a novel nanostructured carbon in the void space between the silicone chains combined with processing at elevated pressure favorably stimulate cellular functions and provide a high degree of cytocompatibility. Furthermore, the high strength-at-break and undiminished intrinsic elongation of silicone are retained. In this regard, we combine here materials science and engineering and cellular biology, to el...Continue Reading

References

Mar 1, 1995·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·G L Polyzois
Jan 23, 2004·Facial Plastic Surgery : FPS·Mark A Erlich, Afshin Parhiscar
Jul 28, 2004·Biomaterials·Annette DienerJoachim Rychly
Dec 6, 2005·Molecular Pharmaceutics·Kumiko AjimaSumio Iijima
Mar 17, 2006·The Journal of Physical Chemistry. B·Kumiko AjimaSumio Iijima
Jul 21, 2006·The Journal of Physical Chemistry. B·Masako YudasakaSumio Iijima
Aug 8, 2006·Molecular Pharmaceutics·Tatsuya MurakamiKiyotaka Shiba
Sep 29, 2006·The Journal of Physical Chemistry. B·Kumiko AjimaSumio Iijima
Dec 26, 2006·Journal of Biomedical Materials Research. Part a·Aylin Sendemir-Urkmez, Russell D Jamison
Mar 6, 2007·Journal of Materials Science. Materials in Medicine·M El FrayP Prowans
Apr 20, 2007·Journal of Materials Science. Materials in Medicine·Paul RoachCarole C Perry
Feb 12, 2009·ACS Nano·Jin MiyawakiSumio Iijima
Jan 8, 2011·Nanotechnology·Takao KasaiAtsuro Yokoyama

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.