Structure, receptor binding, and antigenicity of influenza virus hemagglutinins from the 1957 H2N2 pandemic

Journal of Virology
Rui XuIan A Wilson

Abstract

The hemagglutinin (HA) envelope protein of influenza viruses mediates essential viral functions, including receptor binding and membrane fusion, and is the major viral antigen for antibody neutralization. The 1957 H2N2 subtype (Asian flu) was one of the three great influenza pandemics of the last century and caused 1 million deaths globally from 1957 to 1968. Three crystal structures of 1957 H2 HAs have been determined at 1.60 to 1.75 A resolutions to investigate the structural basis for their antigenicity and evolution from avian to human binding specificity that contributed to its introduction into the human population. These structures, which represent the highest resolutions yet recorded for a complete ectodomain of a glycosylated viral surface antigen, along with the results of glycan microarray binding analysis, suggest that a hydrophobicity switch at residue 226 and elongation of receptor-binding sites were both critical for avian H2 HA to acquire human receptor specificity. H2 influenza viruses continue to circulate in birds and pigs and, therefore, remain a substantial threat for transmission to humans. The H2 HA structure also reveals a highly conserved epitope that could be harnessed in the design of a broader and mo...Continue Reading

References

Aug 1, 1993·The Journal of General Virology·K SugawaraK Nakamura
Aug 1, 1997·The Journal of Infectious Diseases·R G Webster
Nov 24, 1999·The Journal of General Virology·N V MakarovaR G Webster
Aug 31, 2000·Annual Review of Biochemistry·J J Skehel, D C Wiley
Sep 20, 2001·The Journal of General Virology·E TsuchiyaK Nakamura
Sep 29, 2001·Journal of Applied Microbiology·C W Potter
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ron A M FouchierAlbert D M E Osterhaus
May 1, 1997·Acta Crystallographica. Section D, Biological Crystallography·G N MurshudovE J Dodson
Nov 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ola BlixtJames C Paulson
Dec 2, 2004·Acta Crystallographica. Section D, Biological Crystallography·Paul Emsley, Kevin Cowtan
Apr 5, 2005·Acta Crystallographica. Section D, Biological Crystallography·Airlie J McCoyRandy J Read
Sep 13, 2005·Annual Review of Microbiology·Colin R Parrish, Yoshihiro Kawaoka
Sep 30, 2005·The New England Journal of Medicine·John H BeigelUNKNOWN Writing Committee of the World Health Organization (WHO) Consultation on Human Influenza A/H5
Nov 8, 2005·Journal of Clinical Microbiology·K M ButtYi Guan
Feb 6, 2007·Vaccine·Bert E Johansson, Ian C Brett
Oct 19, 2007·Journal of Virology·Yiming BaoDavid Lipman
Dec 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Wenjun MaJürgen A Richt
Apr 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Arun K KashyapRichard A Lerner
Oct 15, 2008·Vaccine·Gregory J TobinPeter L Nara
Feb 24, 2009·Nature Structural & Molecular Biology·Jianhua SuiWayne A Marasco
Mar 3, 2009·Science·Damian C EkiertIan A Wilson
Jul 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gavin J D SmithYi Guan
Jan 1, 1997·Methods in Enzymology·Zbyszek Otwinowski, Wladek Minor

❮ Previous
Next ❯

Citations

Dec 15, 2010·Expert Reviews in Molecular Medicine·Jessica A BelserJacqueline M Katz
Jun 8, 2011·Immunology and Cell Biology·Garry W LynchJohn S Sullivan
Feb 12, 2013·Nature Structural & Molecular Biology·Rui XuIan A Wilson
Jun 12, 2010·The Journal of Biological Chemistry·Steven J Gamblin, John J Skehel
Aug 3, 2011·Glycobiology·Benedict M Sattelle, Andrew Almond
Aug 29, 2012·Infection and Immunity·Anders EsbergNicklas Strömberg
Mar 30, 2012·Journal of Virology·Jens C KrauseJames E Crowe
Nov 10, 2010·PloS One·Karthik ViswanathanRam Sasisekharan
Nov 15, 2013·Journal of Virology·Jeremy C JonesRobert G Webster
Apr 27, 2013·Virus Research·James C Paulson, Robert P de Vries
Apr 22, 2015·Journal of Biomolecular Structure & Dynamics·S Kannan, P Kolandaivel
Mar 27, 2012·Current Opinion in Virology·Masaki Imai, Yoshihiro Kawaoka
Jun 27, 2013·Medicinal Research Reviews·Evelien Vanderlinden, Lieve Naesens
Nov 15, 2013·The Journal of General Virology·Thomas O EdingerSilke Stertz
Jul 19, 2016·Influenza and Other Respiratory Viruses·Udayan JosephGavin J D Smith
Nov 12, 2016·ELife·Marc LipsitchColin A Russell
Jul 18, 2017·International Journal of Molecular Sciences·Lauren Byrd-LeotisDavid A Steinhauer
Feb 6, 2018·Nature Structural & Molecular Biology·Nicholas C Wu, Ian A Wilson
Dec 5, 2017·Journal of Biomolecular Structure & Dynamics·S Kannan, P Kolandaivel
Dec 17, 2014·Journal of Virology·Udayan JosephUNKNOWN CEIRS H2N2 Working Group
Apr 12, 2016·Tuberculosis and Respiratory Diseases·Jae Yeol Kim
Jul 13, 2011·Nature Reviews. Microbiology·Rafael A Medina, Adolfo García-Sastre

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.