Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D).

Gene
Pengfei XuJoachim Bischof

Abstract

Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases are tightly regulated in the cell and play crucial regulatory roles in multiple cellular processes from protozoa to human. Since their dysregulation as well as mutations within their coding regions contribute to the development of various different pathologies, including cancer and neurodegenerative diseases, they have become interesting new drug targets within the last decade. However, to develop optimized CK1 isoform-specific therapeutics in personalized therapy concepts, a detailed knowledge of the regulation and functions of the different CK1 isoforms, their various splice variants and orthologs is mandatory. In this review we will focus on the stress-induced CK1 isoform delta (CK1δ), thereby addressing its regulation, physiological functions, the consequences of its deregulation for the development and progression of diseases, and its potential as therapeutic drug target.

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Citations

Jan 15, 2020·Proceedings of the National Academy of Sciences of the United States of America·Sarah Hanna-AddamsZhigao Wang
Dec 11, 2019·International Journal of Molecular Sciences·Congxing LiuUwe Knippschild
Aug 11, 2020·Frontiers in Cell and Developmental Biology·Yuting LiJuan Wang
Dec 12, 2020·The Biochemical Journal·Luke J Fulcher, Gopal P Sapkota
Oct 30, 2020·Frontiers in Aging Neuroscience·Caroline L Benn, Lee A Dawson
Dec 3, 2020·International Journal of Molecular Sciences·Pavlína JanovskáVítězslav Bryja
Apr 20, 2021·Frontiers in Cellular and Infection Microbiology·Najma RachidiGerald F Späth
Jul 4, 2021·Cancer Epidemiology·Alem A BelachewMichelle A T Hildebrandt
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aileen RothJoachim Bischof

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