Structure-specific nucleic acid recognition by L-motifs and their diverse roles in expression and regulation of the genome

Biochimica Et Biophysica Acta
Roopa Thapar

Abstract

The high-mobility group (HMG) domain containing proteins regulate transcription, DNA replication and recombination. They adopt L-shaped folds and are structure-specific DNA binding motifs. Here, I define the L-motif super-family that consists of DNA-binding HMG-box proteins and the L-motif of the histone mRNA binding domain of stem-loop binding protein (SLBP). The SLBP L-motif and HMG-box domains adopt similar L-shaped folds with three α-helices and two or three small hydrophobic cores that stabilize the overall fold, but have very different and distinct modes of nucleic acid recognition. A comparison of the structure, dynamics, protein-protein and nucleic acid interactions, and regulation by PTMs of the SLBP and the HMG-box L-motifs reveals the versatile and diverse modes by which L-motifs utilize their surfaces for structure-specific recognition of nucleic acids to regulate gene expression.

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Citations

Jun 10, 2017·Cellular and Molecular Life Sciences : CMLS·Andrew C Hausrath, Richard L Kingston
Aug 21, 2021·Seminars in Cancer Biology·Beatrix R Bradford, Chunyuan Jin

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