Structure within eukaryotic cytoplasm and its relationship to glycolytic metabolism

Cell Biochemistry and Function
H R Knull, A P Minton

Abstract

Taken together, the results reviewed here indicate that both structural proteins and enzymes exist in a relatively mobile, uncomplexed form and in a relatively immobile form, complexed with the matrix. The relative amounts of free and complexed forms of each protein are dependent upon the local concentrations of both small molecules and other macromolecules and hence may vary in time and space throughout the cell. Free and cytomatrix-bound enzymes exchange rapidly, while free and cytomatrix-bound structural proteins exchange more slowly. These two distinct time scales suggest that the slowly exchanging structural proteins form the core of fibrous structural elements--having many stabilizing intermolecular contacts with near neighbours--whereas the more rapidly exchanging enzymes adsorb to the surface of the structural elements and have fewer near neighbour contacts. The hierarchical nature of these associations is depicted schematically in Figure 3. Metabolism is proposed to proceed primarily via transport of small metabolites rather than by transport of enzymes, which may be organized in functional clusters to facilitate, metabolic regulation.

References

Jan 1, 1977·Current Topics in Cellular Regulation·J H Ottaway, J Mowbray
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M H HeggenessS J Singer
Dec 1, 1976·The Biochemical Journal·F M Clarke, D J Morton
Jan 13, 1975·Biochimica Et Biophysica Acta·F M Clarke, C J Masters
Jan 1, 1992·Current Topics in Cellular Regulation·J Ovádi, F Orosz
Mar 26, 1990·FEBS Letters·S A JacksonJ S Clegg
Nov 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J J Aragón, A Sols
Mar 1, 1991·Trends in Biochemical Sciences·P Matsudaira
May 1, 1990·Archives of Biochemistry and Biophysics·J S Clegg, S A Jackson
Jul 1, 1990·Biophysical Journal·L HouK Luby-Phelps
Jan 1, 1990·Annual Review of Biochemistry·R B Vallee, H S Shpetner
Sep 1, 1988·The Journal of Cell Biology·L Pagliaro, D L Taylor
Nov 1, 1989·The Journal of Cell Biology·C LeeL B Chen
Feb 1, 1989·Current Opinion in Cell Biology·S Okabe, N Hirokawa
Nov 9, 1989·Biochimica Et Biophysica Acta·J L WalshH R Knull
Mar 1, 1987·The American Journal of Physiology·R M Lynch, R J Paul
Jan 1, 1988·Annual Review of Biophysics and Biophysical Chemistry·K Luby-PhelpsD L Taylor
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K Luby-PhelpsF Lanni
Jan 1, 1986·Annual Review of Biochemistry·T D Pollard, J A Cooper
Oct 1, 1986·The Journal of Cell Biology·M TerasakiK Fujiwara
Jan 1, 1986·Current Topics in Cellular Regulation·D K Srivastava, S A Bernhard
Jul 31, 1987·Biochemical and Biophysical Research Communications·R Karkhoff-Schweizer, H R Knull
Jan 1, 1986·Methods in Enzymology·N Hirokawa
Mar 1, 1986·The Journal of Cell Biology·P A Amato, D L Taylor
Jul 15, 1985·European Journal of Biochemistry·P Huitorel, D Pantaloni
Jun 14, 1972·Nature: New Biology·D S Gilbert
Apr 1, 1969·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P Sigel, D Pette
Jul 17, 1974·Biochimica Et Biophysica Acta·F M Clarke, C J Masters

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Citations

Feb 19, 2000·Current Opinion in Structural Biology·A P Minton
Mar 1, 2000·Trends in Biochemical Sciences·P A Srere
Jul 20, 2001·The International Journal of Biochemistry & Cell Biology·M Al-Habori
Dec 14, 2017·Biophysics Reviews·Germán Rivas, Allen P Minton
Sep 4, 2018·Integrative Biology : Quantitative Biosciences From Nano to Macro·Henrik S ThokeLars F Olsen
Sep 10, 2011·Journal of Osteoporosis·Joonas Sirola, Heikki Kröger
May 26, 2018·Journal of Biological Physics·Henrik Seir ThokeLuis A Bagatolli
Jan 8, 2015·Pflügers Archiv : European journal of physiology·Ryszard GrygorczykSergei N Orlov
Dec 11, 2019·Biophysical Journal·Anne R ShimIgal Szleifer
Jul 11, 2006·Journal of Cell Science·Allen P Minton
Sep 27, 2021·Comprehensive Reviews in Food Science and Food Safety·Yulong BaoRuichang Gao
May 31, 2011·Biochimie·Liliana Hernández-PérezCecilia Montañez
Oct 5, 2011·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Andrea P CayenneJonathon H Stillman

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