Structured antedependence models for functional mapping of multiple longitudinal traits

Statistical Applications in Genetics and Molecular Biology
Wei ZhaoR Wu

Abstract

In this article, we present a statistical model for mapping quantitative trait loci (QTL) that determine growth trajectories of two correlated traits during ontogenetic development. This model is derived within the maximum likelihood context, incorporated by mathematical aspects of growth processes to model the mean vector and by structured antedependence (SAD) models to approximate time-dependent covariance matrices for longitudinal traits. It provides a quantitative framework for testing the relative importance of two mechanisms, pleiotropy and linkage, in contributing to genetic correlations during ontogeny. This model has been employed to map QTL affecting stem height and diameter growth trajectories in an interspecific hybrid progeny of Populus, leading to the successful discovery of three pleiotropic QTL on different linkage groups. The implications of this model for genetic mapping within a broader context are discussed.

Citations

Aug 18, 2009·Journal of Mathematical Biology·Jiangtao LuoRongling Wu
Mar 27, 2013·Advanced Drug Delivery Reviews·Zuoheng WangRongling Wu
Nov 26, 2009·Biological Reviews of the Cambridge Philosophical Society·Yao Li, Rongling Wu
Jan 31, 2007·Theoretical Biology & Medical Modelling·Tian LiuRongling Wu
Apr 23, 2013·Advanced Drug Delivery Reviews·Guodong LiuRongling Wu
May 22, 2010·Trends in Pharmacological Sciences·Kwangmi AhnRongling Wu
Feb 9, 2012·Genetic Epidemiology·Shuang WangFrederica P Perera
Mar 28, 2016·Trends in Genetics : TIG·Xuli ZhuRongling Wu
May 15, 2015·PloS One·Linghua ZhouYunqian Guo
Feb 15, 2011·Drug Discovery Today·Yunqian GuoRongling Wu
Mar 9, 2007·Biometrical Journal. Biometrische Zeitschrift·Anat Reiner-Benaim
Apr 23, 2019·The Plant Journal : for Cell and Molecular Biology·Meixia YeRongling Wu
Feb 6, 2017·Briefings in Bioinformatics·Liyong FuRongling Wu
Mar 19, 2013·Statistical Applications in Genetics and Molecular Biology·Douglas LondonoDerek Gordon
Aug 3, 2018·Nature Communications·Libo JiangRongling Wu
Oct 22, 2019·NPJ Systems Biology and Applications·Chixiang ChenRongling Wu
Oct 11, 2020·NPJ Systems Biology and Applications·Chixiang ChenRongling Wu
Sep 28, 2021·Frontiers in Microbiology·Dengcheng YangRongling Wu
Nov 2, 2021·Frontiers in Genetics·Xiao-Yu ZhangRongling Wu

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