Structured microparticles with tailored properties produced by membrane emulsification

Advances in Colloid and Interface Science
Goran T Vladisavljević

Abstract

This paper provides an overview of membrane emulsification routes for fabrication of structured microparticles with tailored properties for specific applications. Direct (bottom-up) and premix (top-down) membrane emulsification processes are discussed including operational, formulation and membrane factors that control the droplet size and droplet generation regimes. A special emphasis was put on different methods of controlled shear generation on membrane surface, such as cross flow on the membrane surface, swirl flow, forward and backward flow pulsations in the continuous phase and membrane oscillations and rotations. Droplets produced by membrane emulsification can be used for synthesis of particles with versatile morphology (solid and hollow, matrix and core/shell, spherical and non-spherical, porous and coherent, composite and homogeneous), which can be surface functionalised and coated or loaded with macromolecules, nanoparticles, quantum dots, drugs, phase change materials and high molecular weight gases to achieve controlled/targeted drug release and impart special optical, chemical, electrical, acoustic, thermal and magnetic properties. The template emulsions including metal-in-oil, solid-in-oil-in-water, oil-in-oil, m...Continue Reading

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Citations

Nov 15, 2016·Lab on a Chip·Pingan Zhu, Liqiu Wang
Mar 28, 2017·Pharmaceutical Research·Airama AlbisaLidietta Giorno
Mar 27, 2021·Advances in Colloid and Interface Science·Akmal Nazir, Goran T Vladisavljević
Aug 19, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Guorong JiaKai Chen

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