Structured triacylglycerol containing behenic and oleic acids suppresses triacylglycerol absorption and prevents obesity in rats.

Lipids in Health and Disease
Makiko KojimaIkuo Ikeda

Abstract

Dietary 1(3)-behenoyl-2,3(1)-dioleoyl-rac-glycerol (BOO) has been reported to inhibit pancreatic lipase activity in vitro and suppress postprandial hypertriacylglycerolemia in humans. In the present study, the anti-obesity activities of BOO and its inhibitory effects on lymphatic triacylglycerol (TAG) absorption were investigated in rats. In Experiment 1, rats were fed either BOO or soybean oil (SO) diet for 6 weeks. In the BOO diet, 20% of SO was replaced with an experimental oil rich in BOO. In Experiments 2 and 3, rats cannulated in the thoracic duct were administered an emulsions containing trioleoylglycerol (OOO) or an oil mixture (OOO:BOO, 9:1). Tri[1-14C]oleoylglycerol (14C-OOO) was added to the emulsions administered in Experiment 3. No observable differences were detected in food intake or body weight gain between the BOO and SO groups in Experiment 1. Plasma and liver TAG concentrations and visceral fat weights were significantly lower in the BOO group than in the SO group. The apparent absorption rate of fat was significantly lower in the BOO group than in the SO group. In Experiment 2, the lymphatic recovery of oleic and behenic acids was significantly lower at 5 and 6 h after BOO administration than after OOO admin...Continue Reading

References

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Citations

Jun 13, 2013·The British Journal of Nutrition·Shiou Wah GoukCheng Hock Chuah
May 12, 2015·Biotechnology Progress·Daniel K Y SolaimanNicole V Crocker
Sep 23, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura J W KeppleyTodd E Fox
Aug 28, 2020·Food & Function·Takumi TakahashiKiyotaka Nakagawa
Sep 29, 2018·Food Science and Biotechnology·Wai-Ming KokSit-Foon Cheng
Apr 19, 2017·Journal of Food Science and Technology·Marilene D M Morselli RibeiroLireny A G Gonçalves

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