PMID: 698239Sep 28, 1978Paper

Structures and fatty acid compositions of neutral glycosphingolipids of human plasma

Biochimica Et Biophysica Acta
J KościelakB Cedergren

Abstract

Major neutral glycosphingolipids were isolated from human plasma and their structures and fatty acid compositions studied. The four neutral glycosphingolipids of plasma were characterized as Glc beta(1 leads to 1)ceramide, Gal beta(1 leads to 1)- ceramide, Gal beta(1 leads to 4) Glc beta (1 leads to 1)ceramide, Gal alpha(1 leads to 4) Gal beta(1 leads to 4) Glc beta(1 leads to 1)ceramide and GalNAc beta(1 leads to 3) Gal (1 leads to 4) Gal (1 leads to 4) Glc beta(1 leads to 1)-ceramide. The glycosphingolipids contained mostly short chain fatty acids of which most prominent was C16. Erythrocyte glucosylceramide and lactosylceramide exhibited similar fatty acid compositions as their plasma counterparts. Triglycosylceramide and globoside of erythrocytes contained almost exclusively long-chain fatty acids. In lactosylceramide obtained from "p" erythrocytes, an accumulation of long-chain fatty acids was found; this accumulation was not observed, however, in lactosylceramide isolated from "p" plasma. It was concluded that plasma and erythrocyte glycosphingolipids are synthesized at separate sites where short- and long-chain fatty acids, respectively, are available. Plasma and erythrocyte glucosylceramide, and probably a fraction of l...Continue Reading

References

Jul 15, 1976·FEBS Letters·J KościelakB Cedergren
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·D M MarcusS K Kundu
Jan 1, 1975·Vox Sanguinis·C A TilleyJ R Wherrett
Jan 3, 1973·European Journal of Biochemistry·A Gardas, J Kościelak
Aug 1, 1967·The Biochemical Journal·V P SkipskiF M Archibald
Aug 27, 1963·Biochimica Et Biophysica Acta·E SVENNERHOLM, L SVENNERHOLM

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Citations

Jul 31, 2010·Journal of Lipid Research·Oswald QuehenbergerEdward A Dennis
Sep 8, 1980·FEBS Letters·M E BreimerB E Samuelsson
Jul 16, 1982·Biochimica Et Biophysica Acta·E ZdebskaJ Kościelak
May 12, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·S RoyP Chaminade

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