Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway.

Immunity
Xuewu ZhangZhijian J Chen

Abstract

Besides its role as the blueprint of life, DNA can also alert the cell to the presence of microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that triggers the innate immune response is cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) (cGAMP) synthase (cGAS), which produces the second messenger cGAMP. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators. Recent research has demonstrated an expanding role of the cGAS-cGAMP-STING pathway in many physiological and pathological processes, including host defense against microbial infections, anti-tumor immunity, cellular senescence, autophagy, and autoimmune and inflammatory diseases. Biochemical and structural studies have elucidated the mechanism of signal transduction in the cGAS pathway at the atomic resolution. This review focuses on the structural and mechanistic insights into the roles of cGAS and STING in immunity and diseases revealed by these recent studies.

References

Jun 19, 2007·Cell·Daniel PanneStephen C Harrison
May 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Wenxiang SunZhengfan Jiang
Aug 14, 2010·European Journal of Immunology·Yanick J Crow
Mar 8, 2012·Science Signaling·Yasuo Tanaka, Zhijian J Chen
May 24, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xiaolei MaErin C Dueber
Jun 26, 2012·Nature Structural & Molecular Biology·Yi-He HuangXiao-Dong Su
Jun 26, 2012·Nature Structural & Molecular Biology·Guijun ShangLichuan Gu
Nov 8, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jeonghyun AhnGlen N Barber
Jan 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jesse DonovanAlexei Korennykh
Mar 5, 2013·Cell Reports·Amede LarabiDaniel Panne
Mar 9, 2013·Microbiology and Molecular Biology Reviews : MMBR·Ute RömlingMark Gomelsky
Mar 23, 2013·Acta Crystallographica. Section D, Biological Crystallography·Ko-Hsin ChinShan-Ho Chou
Apr 23, 2013·The EMBO Journal·Taner CavlarVeit Hornung
Jun 1, 2013·Nature·Filiz CivrilKarl-Peter Hopfner
Apr 29, 2014·Molecular Cell·Xin CaiZhijian J Chen
Jul 17, 2014·The New England Journal of Medicine·Y LiuR Goldbach-Mansky
Aug 19, 2014·Cell·Philip J KranzuschJennifer A Doudna
Oct 19, 2014·Proceedings of the National Academy of Sciences of the United States of America·Marta Lopez-PelaezPhilip Cohen
Oct 19, 2014·Proceedings of the National Academy of Sciences of the United States of America·Junyao RenZhijian J Chen
Nov 18, 2014·The Journal of Clinical Investigation·Nadia JeremiahFrédéric Rieux-Laucat
Dec 3, 2014·Current Opinion in Immunology·Yanick J Crow

❮ Previous
Next ❯

Citations

Jan 25, 2021·Journal of Experimental & Clinical Cancer Research : CR·Qiongyuan HuWenxian Guan
Feb 23, 2021·American Journal of Physiology. Renal Physiology·Wei GongZhanjun Jia
Feb 26, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shan-Shan ZouJingtao Chen
Apr 9, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xia ChenHui Xiao
May 22, 2021·Cell Communication and Signaling : CCS·Lu ZhouLu Zhang
Jun 6, 2021·Nature Reviews. Molecular Cell Biology·Ning Jia, Dinshaw J Patel
May 20, 2021·Science Immunology·Minghua LiSara Cherry
May 22, 2021·Osteoarthritis and Cartilage·Qiang GuoYaosen Wu
Jun 11, 2021·Molecular Cell·Li WanJesper Q Svejstrup
Jun 29, 2021·Frontiers in Immunology·Xiuzhi JiaWei Zhao
Jul 25, 2021·International Journal of Molecular Sciences·Bingqing ZhengJian Zhang
Aug 11, 2021·Viruses·Chase KangasBin He
Aug 13, 2021·JHEP Reports : Innovation in Hepatology·Ruihan ChenQi Ling
Oct 12, 2021·Expert Review of Vaccines·Daniel MekonnenTengchuan Jin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.