Structures and organisation of AAA+ enhancer binding proteins in transcriptional activation

Journal of Structural Biology
Jörg SchumacherMartin Buck

Abstract

Initiation of transcription is a major point of transcriptional regulation and invariably involves the transition from a closed to an open RNA polymerase (RNAP) promoter complex. In the case of the sigma(54)-RNAP, this multi step process requires energy, provided by ATP hydrolysis occurring within the AAA+ domain of enhancer binding proteins (EBPs). Typically, EBPs have an N-terminal regulatory domain, a central AAA+ domain that directly contacts sigma(54) and a C-terminal DNA binding domain. The following AAA+ EBP crystal structures have recently become available: heptameric AAA+ domains of NtrC1 and dimeric NtrC1 with its regulatory domain, hexameric AAA+ domains of ZraR with DNA binding domains, apo and nucleotide bound forms of the AAA+ domain of PspF as well as a cryo-EM structure of the AAA+ domain of PspF complexed with sigma(54). These AAA+ domains reveal the structural conservation between EBPs and other AAA+ domains. EBP specific structural features involved in substrate remodelling are located proximal to the pore of the hexameric ring. Parallels with the substrate binding elements near the central pore of other AAA+ members are drawn. We propose a structural model of EBPs in complex with a sigma(54)-RNAP-promoter co...Continue Reading

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Citations

Feb 10, 2009·Nature Structural & Molecular Biology·Takahide KonKazuo Sutoh
Apr 28, 2009·Nucleic Acids Research·Yi-Xin HuoYi-Ping Wang
Aug 31, 2012·Microbiology and Molecular Biology Reviews : MMBR·Matthew Bush, Ray Dixon
Feb 20, 2010·BMC Microbiology·Sandrine KoechlerPhilippe N Bertin
May 10, 2008·Genome Biology·Jamie SniderWalid A Houry
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Jul 4, 2012·Annual Review of Microbiology·Julie M SilvermanJoseph D Mougous
Jul 3, 2007·Journal of Bacteriology·Cecilia M ArraianoJörg Vogel
Sep 24, 2013·Journal of Molecular Biology·Nan ZhangMartin Buck
Apr 10, 2009·Journal of Molecular Biology·Patricia C BurrowsMartin Buck
Nov 4, 2008·Journal of Molecular Biology·Karen M DaviesLouise N Johnson
Oct 9, 2007·Current Opinion in Structural Biology·Jon Marles-Wright, Richard J Lewis
Nov 13, 2007·Trends in Microbiology·L Lauren BeckTimothy R Hoover
Dec 18, 2007·Journal of Molecular Biology·Nicolas JolyXiaodong Zhang
Nov 17, 2007·Journal of Molecular Biology·Patricia C BurrowsMartin Buck
Sep 26, 2013·Biochemical Society Transactions·Baojun WangJörg Schumacher
Sep 13, 2011·Biochimica Et Biophysica Acta·Nicolas JolyXiaodong Zhang
Nov 9, 2010·FEMS Microbiology Reviews·Victoria Shingler
Jul 16, 2010·FEMS Microbiology Reviews·Tamaswati GhoshXiaodong Zhang
Dec 13, 2006·Current Opinion in Structural Biology·Mathieu RappasXiaodong Zhang
Jul 5, 2008·Journal of Molecular Biology·Jörg SchumacherMartin Buck
Jul 30, 2014·Frontiers in Plant Science·Jörg SchumacherMartin Buck
Oct 26, 2006·Nucleic Acids Research·Alessandro CostaSilvia Onesti
Mar 12, 2008·Molecular Microbiology·Sivaramesh WigneshwerarajMartin Buck

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