Structures and properties of naturally occurring polyether antibiotics

BioMed Research International
Jacek Rutkowski, Bogumil Brzezinski

Abstract

Polyether ionophores represent a large group of natural, biologically active substances produced by Streptomyces spp. They are lipid soluble and able to transport metal cations across cell membranes. Several of polyether ionophores are widely used as growth promoters in veterinary. Polyether antibiotics show a broad spectrum of bioactivity ranging from antibacterial, antifungal, antiparasitic, antiviral, and tumour cell cytotoxicity. Recently, it has been shown that some of these compounds are able to selectively kill cancer stem cells and multidrug-resistant cancer cells. Thus, they are recognized as new potential anticancer drugs. The biological activity of polyether ionophores is strictly connected with their molecular structure; therefore, the purpose of this paper is to present an overview of their formula, molecular structure, and properties.

References

Mar 6, 1979·Biological cybernetics·L M Ricciardi
Feb 1, 1979·Journal of Clinical Pathology·P E Undrill, S C Frazer
Sep 1, 1978·The Journal of Antibiotics·W C LiuE Meyers
Sep 1, 1978·The Journal of Antibiotics·C Keller-JuslénA von Wartburg
Jul 1, 1977·The Journal of Antibiotics·J W WestleyC M Liu
Jan 1, 1976·The Journal of Antibiotics·N TsujiY Kawamura
Oct 27, 1975·Biochemical and Biophysical Research Communications·M MitaniY Miyazaki
Oct 1, 1990·Journal of Industrial Microbiology·J P DirlamA P Ricketts
Oct 1, 1992·The Journal of Antibiotics·S FunayamaSatoshi Omura
Jul 1, 1992·The Journal of Antibiotics·J P DirlamL Presseau-Linabury
May 1, 1992·The Journal of Antibiotics·E J TynanW C Wernau
May 7, 1990·Biochimica Et Biophysica Acta·H H MollenhauerL D Rowe
Nov 1, 1990·British Journal of Plastic Surgery·B Haeseker
Mar 1, 1990·The Journal of Antibiotics·M HatsuH Yamamoto
Apr 1, 1990·The Journal of Antibiotics·Y TakahashiT Takeuchi
Jun 1, 1990·The Journal of Antibiotics·J P DirlamD A Koss
Jan 1, 1989·Current Opinion in Immunology·R L Powles
Feb 1, 1988·Applied and Environmental Microbiology·C J NewboldA J Richardson
Nov 1, 1987·The Journal of Antibiotics·J BordnerE B Whipple
Dec 1, 1974·FEBS Letters·G GrenierJ E Dumont
Nov 1, 1974·The Journal of Antibiotics·Y MiyazakiC Hirsoe
Nov 1, 1974·The Journal of Antibiotics·F KitameM Kikuchi
Oct 25, 1967·Journal of the American Chemical Society·A AgtarapL Steinrauf
Nov 1, 1984·Neurology·A HijdraH van Crevel
Jan 1, 1983·Journal of Chronic Diseases·M Wasow
Apr 1, 1981·British Journal of Plastic Surgery·C B CuttingF Finseth
Dec 1, 1980·The Journal of Antibiotics·Y KusakabeA Seino
Apr 1, 1995·Natural Product Reports·C J DuttonC B Cooper
Jan 1, 1993·The Journal of Antibiotics·J MouslimJ C Tabet
Feb 17, 1993·Molecular and Cellular Biochemistry·T YamauchiT Ohno
Nov 12, 1998·Chemical & Pharmaceutical Bulletin·A M DelortF G Riddle
Jan 7, 2004·Anaesthesia·J Hillier, C Gillbe
Apr 1, 2008·Bioorganic & Medicinal Chemistry Letters·Adam HuczyńskiFranz Bartl
Jun 6, 2009·Angewandte Chemie·Zhanghua GaoPhilip J Kocienski
Sep 15, 2009·Journal of Inorganic Biochemistry·Ivayla N PantchevaWilliam S Sheldrick
Sep 22, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ivayla N PantchevaWilliam S Sheldrick
Dec 8, 2011·Chemical Biology & Drug Design·Adam Huczyński
May 9, 2012·Biochimica Et Biophysica Acta·Adam HuczyńskiBogumil Brzezinski
Jun 23, 2012·Bioorganic & Medicinal Chemistry Letters·Adam HuczyńskiBogumil Brzezinski

Citations

Apr 29, 2014·Journal of Molecular Modeling·Pei Meng WoiYatimah Alias
Jun 11, 2015·Chemical Biology & Drug Design·Michał AntoszczakAdam Huczyński
Nov 20, 2015·The Journal of Physical Chemistry. B·Cheng-Tsung LaiGeorge C Schatz
Jun 22, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Jacek RutkowskiFranz Bartl
Aug 13, 2013·Bioorganic & Medicinal Chemistry Letters·Adam HuczyńskiBogumil Brzezinski
Mar 19, 2015·BioMed Research International·Rosa Estela Quiroz-Castañeda, Edgar Dantán-González
Mar 5, 2015·Chemical Society Reviews·Sherif I ElshahawiJon S Thorson
Jun 16, 2018·Antibiotics·Marianna IorioStefano Donadio
Mar 1, 2015·Applied and Environmental Microbiology·Xiaoxuan GuoYing Huang
Sep 29, 2018·Cancers·Vivek KaushikAnand K V Iyer
Jan 24, 2020·The Journal of Veterinary Medical Science·Marta DecRenata Urban-Chmiel
Jun 18, 2015·Chembiochem : a European Journal of Chemical Biology·Carolina Cano-PrietoCarlos Olano
Sep 5, 2020·Pharmaceuticals·Aleksandra HecelMagdalena Rowińska-Żyrek
Oct 3, 2020·Environmental Science and Pollution Research International·Ekaterina PavlovaJuliana Ivanova
Mar 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lawrence Nnamdi ObasiAlfred Ezinna Ochonogor
Jul 16, 2020·Biomolecules·Michał SulikMichał Antoszczak
Oct 6, 2015·Journal of Environmental Quality·Sarah A DoydoraChing-Hua Huang
Dec 8, 2015·Journal of Environmental Quality·Sarah A DoydoraChing-Hua Huang
Sep 23, 2020·Pharmaceuticals·Phanankosi MoyoLyn-Marié Birkholtz
Jan 29, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Guanzhuang GaoQiaoming Zhi

Methods Mentioned

BETA
X-ray

Related Concepts

Antibiotics
Antineoplastic Agents
Ionophores
Streptomyces
Neoplastic Colony-Forming Units
Antibiotic Resistance, Neoplasm
Antiviral Agents
Plasma Membrane
Lipids
Promoter

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