Structures and proton-pumping strategies of mitochondrial respiratory enzymes

Annual Review of Biophysics and Biomolecular Structure
B E Schultz, S I Chan

Abstract

Enzymes of the mitochondrial respiratory chain serve as proton pumps, using the energy made available from electron transfer reactions to transport protons across the inner mitochondrial membrane and create an electrochemical gradient used for the production of ATP. The ATP synthase enzyme is reversible and can also serve as a proton pump by coupling ATP hydrolysis to proton translocation. Each of the respiratory enzymes uses a different strategy for performing proton pumping. In this work, the strategies are described and the structural bases for the action of these proteins are discussed in light of recent crystal structures of several respiratory enzymes. The mechanisms and efficiency of proton translocation are also analyzed in terms of the thermodynamics of the substrate transformations catalyzed by these enzymes.

References

Feb 1, 1979·Archives of Biochemistry and Biophysics·Y M Galante, Y Hatefi
Apr 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·B ChanceJ S Leigh
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·F J RuzickaR H Sands
Oct 21, 1976·Journal of Theoretical Biology·P Mitchell
Jul 17, 1992·Biochimica Et Biophysica Acta·R MitchellP R Rich
May 1, 1992·Comparative Biochemistry and Physiology. Comparative Physiology·W D Melrose, S C Nicol
Aug 1, 1992·Quarterly Reviews of Biophysics·J E Walker
May 23, 1991·Biochimica Et Biophysica Acta·R P Ambler
Jan 1, 1990·Annual Review of Biophysics and Biophysical Chemistry·A E Senior
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S W HanD L Rousseau
Jun 1, 1990·Microbiological Reviews·B L Trumpower
Jan 1, 1989·Archives of Biochemistry and Biophysics·B A AckrellG Cecchini
Apr 1, 1987·Journal of Bioenergetics and Biomembranes·L J Prochaska, P S Fink
Jun 1, 1985·Biochemical Society Transactions·D Simpkin, W J Ingledew
Dec 11, 1974·Biochemical and Biophysical Research Communications·T OnishiT E King
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M Wikström
May 25, 1982·Biochemistry·D BickarC Bonaventura
Apr 9, 1984·Biochimica Et Biophysica Acta·P R Rich
Jun 1, 1984·Biochemical Society Transactions·A L Lehninger

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Citations

Jul 19, 2013·Journal of Biological Physics·L KavithaD Gopi
Nov 18, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ying LiIgor Kyrychenko
Dec 15, 2006·Journal of the American Chemical Society·Demian RiccardiQiang Cui
Apr 2, 2005·Nature Reviews. Molecular Cell Biology·Tracey A Rouault, Wing-Hang Tong
Jun 21, 2007·Chemical Communications : Chem Comm·Joel RosenthalDaniel G Nocera
Oct 3, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Helder M Marques
May 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sunney I Chan
Sep 9, 2011·The Journal of Biological Chemistry·Adam J CornishEric L Hegg
Apr 5, 2012·The Journal of Biological Chemistry·Matthew B McNeilPeter C Fineran
Jun 6, 2012·The Journal of Biological Chemistry·Yong ChenXinmin Cao
May 9, 2006·Antioxidants & Redox Signaling·Giorgio LenazGiancarlo Solaini
Feb 22, 2008·Molecular Biology of the Cell·Hao Lu, Xinmin Cao
Mar 28, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexandra V AndreevaTatyana A Voyno-Yasenetskaya
Oct 7, 2003·Annual Review of Biochemistry·Gary Cecchini
May 7, 2009·Annual Review of Biophysics·Sunney I Chan
Feb 24, 2004·Annual Review of Physiology·Antony R Crofts
Jul 16, 2009·Journal of Leukocyte Biology·Yanlin WangDavid Sheikh-Hamad
Nov 19, 2013·Journal of Dairy Science·Francesca LositoGiovanni Antonini
Oct 24, 2001·Trends in Genetics : TIG·H T Jacobs
Feb 8, 2006·FEBS Letters·Fraser MacMillanHartmut Michel
May 28, 2015·Protein Science : a Publication of the Protein Society·Yu-Ming M HuangChia-En A Chang
Jun 3, 2011·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Macario Genaro Matus-OrtegaJuan Pablo Pardo
Mar 15, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Salvatore NesciAlessandra Pagliarani
Sep 14, 2010·Respiratory Physiology & Neurobiology·Yang WangDavid Gozal
Jun 17, 2009·Seminars in Cell & Developmental Biology·Xinmin Cao, Yong Chen
May 9, 2007·Mitochondrion·Giorgio LenazMaria Luisa Genova
Nov 14, 2015·Cell Reports·Hyoung-Tai KimJin Woo Kim
Sep 29, 2012·Microscopy Research and Technique·Belinda K WrightEnrico Gratton
Oct 2, 2004·Progress in Lipid Research·Raymond C Valentine, David L Valentine
Jul 3, 2003·Biochimica Et Biophysica Acta·Judy HirstJohn E Walker
Oct 12, 2007·Journal of Biochemistry and Molecular Biology·Mehmet OzturkSevnur Mandaci
Jul 24, 2010·Biochimica Et Biophysica Acta·Armen Y Mulkidjanian
Sep 20, 2011·Biochimica Et Biophysica Acta·Masakazu MimakiMichael T Ryan
Dec 3, 2011·Pharmaceutical Biology·P N ShilpaSivasitambaram Niranjali Devaraj
Aug 28, 2010·Mitochondrial DNA·Nathan C SheffieldMichael F Whiting

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Methods Mentioned

BETA
X-ray
NMR
electron paramagnetic resonance
electron microscopy

Software Mentioned

Raster3D
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