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Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs

Nature Structural & Molecular Biology

Nov 6, 2019

David R. BoyerDavid S. Eisenberg

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Abstract

Deposits of amyloid fibrils of α-synuclein are the histological hallmarks of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy, with hereditary mutations in α-synuclein linked to the first two of these conditions. Seeing the changes to the structures of amyloid ...read more

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Hydrogen
Parkinson Disease
Lewy Bodies
Germ-Line Mutation
Fibril - Cell Component
Alpha-Synuclein
Atrophic
Dementia
Cytotoxicity
Mutant
21
1
10
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Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs

Nature Structural & Molecular Biology

Nov 6, 2019

David R. BoyerDavid S. Eisenberg

PMID: 31695184

DOI: 10.1038/s41594-019-0322-y

Abstract

Deposits of amyloid fibrils of α-synuclein are the histological hallmarks of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy, with hereditary mutations in α-synuclein linked to the first two of these conditions. Seeing the changes to the structures of amyloid ...read more

Mentioned in this Paper

Hydrogen
Parkinson Disease
Lewy Bodies
Germ-Line Mutation
Fibril - Cell Component
21
1
10

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