PMID: 9438871DOI: 10.1016/s0969-2126(97)00304-3Feb 7, 1998Paper
Structures of staurosporine bound to CDK2 and cAPK--new tools for structure-based design of protein kinase inhibitors
Structure
L M Toledo, N Lydon
Abstract
Protein kinases are involved in a wide variety of signal transduction processes; their deregulation has been implicated in a number of human diseases, including cancer and disorders of the immune system. The recently determined structures of two protein kinases, cAPK and CDK2, in complex with an inhibitor, staurosporine, provide a detailed account of inhibitor-kinase interactions and inhibitor selectivity.
References
Jan 1, 1992·Journal of Medicinal Chemistry·P D DavisS E Turner
Jul 26, 1991·Science·D R KnightonJ M Sowadski
Jul 26, 1991·Science·D R KnightonJ M Sowadski
Apr 20, 1990·Cell·A Ullrich, J Schlessinger
Aug 31, 1990·Biochemical and Biophysical Research Communications·J M HerbertJ P Maffrand
Jul 1, 1988·Science·S K HanksT Hunter
Aug 1, 1995·Proteins·U Schulze-GahmenS H Kim
Dec 1, 1994·Current Opinion in Structural Biology·S CoxS S Taylor
Sep 15, 1994·Experientia·P A HortonL M Ballas
May 15, 1994·Structure·S S Taylor, E Radzio-Andzelm
Jun 17, 1993·Nature·H L De BondtS H Kim
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·W F De AzevedoS H Kim
Jun 7, 1996·Journal of Medicinal Chemistry·P M TraxlerN Lydon
Dec 1, 1995·Journal of Computer-aided Molecular Design·P FuretP Traxler
Jan 13, 1998·Biochimica Et Biophysica Acta·K S Kolibaba, B J Druker
Feb 7, 1998·Structure·L PradeD Bossemeyer
May 1, 1993·Acta Crystallographica. Section D, Biological Crystallography·D R KnightonJ M Sowadski
❮ Previous
Next ❯
Citations
Jun 1, 2001·Advances in Enzyme Regulation·R A Engh, D Bossemeyer
Aug 24, 1999·Pharmacology & Therapeutics·J M SowadskiR Karlsson
Jun 19, 2001·Biochimica Et Biophysica Acta·C C KumarL Xiao
May 9, 2000·Critical Reviews in Oncology/hematology·A Gescher
Jan 16, 1999·Chemistry & Biology·S V Frye
Jan 10, 2009·The Journal of Antibiotics·Hirofumi Nakano, Satoshi Omura
Nov 23, 2006·Natural Product Reports·César SánchezJosé A Salas
Jun 17, 2004·The Journal of Clinical Investigation·Jing ChenD Gary Gilliland
Oct 7, 2005·Biological Chemistry·Matthias BureikRita Bernhardt
Mar 27, 2010·Neurochemical Research·Lina JiVed Chauhan
Jul 26, 2015·Journal of Biomolecular Structure & Dynamics·Minhajul ArfeenPrasad V Bharatam
Nov 13, 2015·European Journal of Medicinal Chemistry·Mudasir MaqboolNasimul Hoda
Jun 21, 2011·Journal of Cellular Biochemistry·Syeda Tasneem TowhidFlorian Lang
Mar 24, 2016·ChemMedChem·Alexander J M DisneyLodewijk V Dekker
Sep 9, 2015·Organic Letters·Kanako Nozawa-KumadaYoshinori Kondo
Dec 24, 2003·Analytical Biochemistry·I MuckenschnabelI Filipuzzi
Aug 3, 2005·Chemistry : a European Journal·Simon BarrettThomas Woodhall
Mar 3, 2005·Angewandte Chemie·Douglas S WilliamsEric Meggers
Dec 29, 2005·Angewandte Chemie·Judit E DebreczeniEric Meggers
Aug 19, 2014·Cellular Microbiology·Katia FettucciariPierfrancesco Marconi
Dec 10, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hichem GallalaRainer Probstmeier
Jul 15, 1999·Structure·X ZhuK A Morgenstern
Jun 5, 2003·Cancer Cell·Jan CoolsD Gary Gilliland
Nov 17, 2006·Organic Letters·Howard Bregman, Eric Meggers
Feb 14, 2004·Organic Letters·Lilu ZhangEric Meggers
Apr 11, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Syed M QadriFlorian Lang
Feb 26, 2005·Organic & Biomolecular Chemistry·Javier López-PradosManuel Martín-Lomas
Apr 5, 2007·Organic & Biomolecular Chemistry·Nicholas PaganoEric Meggers
Jan 5, 2002·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·M MaekawaM Munakata
Oct 19, 2013·Molecular Pharmacology·Naoko Shimada-ShimizuShigeo Wakabayashi
Aug 5, 2004·The Journal of Biological Chemistry·Lei JinKatherine J Seidl
Jul 24, 2007·Journal of Biomolecular Screening·Connie S LebakkenKurt W Vogel
Jun 9, 2006·Acta Biochimica Et Biophysica Sinica·Tian-Jun ZhouElizabeth J Goldsmith
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Chaves-DiasM A Beaven
Feb 24, 2007·Journal of Medicinal Chemistry·Dubravko JelićWolfgang Brandt
Nov 11, 1998·General Pharmacology·A Gescher
Oct 21, 2004·Journal of the American Chemical Society·Howard BregmanEric Meggers
Aug 18, 2005·Journal of the American Chemical Society·Stephen BartlettStuart L Warriner
Jan 19, 2006·Journal of the American Chemical Society·Howard BregmanEric Meggers
May 11, 2002·The Journal of Organic Chemistry·Ted L UnderinerJasbir Singh
Feb 25, 1999·Biochemistry·N NarayanaS S Taylor
Dec 26, 2001·Chemical Reviews·A J Bridges
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