Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI)

Circulation. Cardiovascular Interventions
Giulio GuagliumiMarco Costa

Abstract

Polymer-coated drug-eluting stents are effective in preventing restenosis but have been associated with delayed healing and incomplete strut coverage. It is unknown whether paclitaxel-eluting stents (PES) with minimal biodegradable abluminal coating enhances strut coverage while preventing neointimal hyperplasia. Using optical coherence tomography (OCT) as a primary imaging modality, we assessed the proportion of uncovered struts at 6-month follow-up in PES coated with durable versus ultrathin (<1 microm) biodegradable abluminal polymers. In this pilot trial, 60 patients with de novo lesions (< or =25 mm) in native coronary vessels were randomly assigned to receive either TAXUS Liberté PES or JACTAX PES, a Liberté stent with polymer deposited abluminally as microdots (JACTAX HD: 9.2 microg each of polymer and paclitaxel per 16-mm stent; JACTAX LD: 5 microg each). OCT follow-up occurred at 6 months with clinical follow-up through 1 year. The primary end point was percent uncovered struts by OCT. An independent core laboratory blinded to stent assignment analyzed images. The 6-month rate of uncovered struts per patient was 5.3+/-14.7% for TAXUS Liberté, 7.0+/-12.2% for JACTAX HD, and 4.6+/-7.3% for JACTAX LD (P=0.81); percent mal...Continue Reading

References

Oct 3, 2003·The New England Journal of Medicine·Jeffrey W MosesUNKNOWN SIRIUS Investigators
Jan 16, 2004·The New England Journal of Medicine·Gregg W StoneUNKNOWN TAXUS-IV Investigators
Jun 13, 2006·The American Journal of Cardiology·Teruyoshi KumeKiyoshi Yoshida
Feb 14, 2007·The New England Journal of Medicine·Gregg W StoneMartin B Leon
May 2, 2007·Circulation·Donald E CutlipUNKNOWN Academic Research Consortium
May 19, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Aloke V FinnRenu Virmani
Jul 26, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Giulio Guagliumi, Vasile Sirbu
Apr 16, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroki KatohKen-ichi Hirata
May 26, 2009·JACC. Cardiovascular Interventions·John A OrmistonDonald S Baim
Jun 17, 2009·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Nieves GonzaloEvelyn Regar
Nov 21, 2009·JACC. Cardiovascular Interventions·Hiram G BezerraDaniel I Simon
May 22, 2010·JACC. Cardiovascular Interventions·Giulio GuagliumiUNKNOWN ODESSA Trial Investigators

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Citations

May 26, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Li ShenJunbo Ge
Apr 4, 2013·Heart, Lung & Circulation·Anthony M SammelNigel Jepson
Feb 15, 2012·European Heart Journal Cardiovascular Imaging·Juan Luis Gutiérrez-ChicoCarlo di Mario
Mar 19, 2011·Vascular Health and Risk Management·Davide CapodannoCorrado Tamburino
Oct 12, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Juan Luis Gutiérrez-ChicoPatrick W Serruys
Jul 17, 2012·Current Cardiovascular Imaging Reports·Antonios KaranasosEvelyn Regar
Feb 22, 2011·The International Journal of Cardiovascular Imaging·Emile Aziz MehannaHiram Grando Bezerra
Mar 12, 2011·The International Journal of Cardiovascular Imaging·Satoko TaharaMarco Costa
Apr 27, 2012·The International Journal of Cardiovascular Imaging·Guilherme F Attizzani, Hiram G Bezerra
Jul 17, 2012·Current Cardiovascular Imaging Reports·Milosz Jaguszewski, Ulf Landmesser
Feb 5, 2013·Journal of Biotechnology·Aaron TanAlexander M Seifalian
Jan 29, 2013·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Tomohisa TadaAdnan Kastrati
Jan 10, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Nadja BegeThomas Kissel
Mar 1, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wahid KhanAbraham J Domb
Jan 4, 2012·Pharmacology & Therapeutics·Michail I PapafaklisLampros K Michalis
Mar 21, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Giulio GuagliumiMarco A Costa
Apr 11, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Aristotelis C PapayannisEmmanouil S Brilakis
Jul 4, 2015·Annals of Biomedical Engineering·Barry O'BrienFaisal Sharif
Jan 3, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Nadja BegeThomas Kissel
Feb 18, 2014·Journal of the American College of Cardiology·Guilherme F AttizzaniCorrado Tamburino
Apr 22, 2016·European Heart Journal Cardiovascular Imaging·Mario IannacconeGregg W Stone
Jan 14, 2012·JACC. Cardiovascular Imaging·Masataka NakanoRenu Virmani
Sep 10, 2010·Journal of the American College of Cardiology·Scot Garg, Patrick W Serruys
Feb 3, 2012·Circulation. Cardiovascular Interventions·Giulio GuagliumiMarco A Costa
Feb 10, 2012·Circulation. Cardiovascular Interventions·Juan Luis Gutiérrez-ChicoPatrick W Serruys
Apr 30, 2013·Expert Review of Cardiovascular Therapy·Wail NammasEvelyn Regar
Nov 20, 2012·Biomedical Optics Express·Hong LuDavid L Wilson
Sep 8, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Stefan VerheyeAntonio Colombo
May 10, 2021·Biomedical Engineering Online·Joseph Robert StevensMohammad Akrami

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