Strychnine blocks inhibitory postsynaptic potentials elicited in masseter motoneurons by sensory stimuli during carbachol-induced motor atonia

Neuroscience
K A KohlmeierM H Chase

Abstract

In previous studies we reported that large-amplitude inhibitory potentials were elicited in masseter motoneurons by auditory stimuli (95-dB clicks) and stimulation of the sciatic nerve in alpha-chloralose-anesthetized cats [Kohlmeier K. A. et al. (1994) Soc. Neurosci. Abstr. 20, 1218; Kohlmeier K. A. et al. (1995) Sleep Res. 24, 9]. These potentials were always elicited during motor atonia induced by the pontine injection of carbachol into the nucleus pontis oralis and were never elicited prior to atonia. In the present report, the hyperpolarizing potentials that arose in response to clicks and stimulation of the sciatic nerve were blocked following the juxtacellular application of strychnine, a glycinergic antagonist. In contrast, bicuculline, a GABA(A) receptor antagonist, did not suppress the carbachol-dependent hyperpolarizing potentials elicited by these stimuli. In some motoneurons, blockade of the inhibitory potential by strychnine revealed a depolarizing potential. These data suggest that clicks and stimulation of the sciatic nerve not only elicit inhibition of motoneurons but also activate an excitatory drive which is masked by elicited inhibitory postsynaptic potentials. These findings suggest that glycine is likely t...Continue Reading

References

Jan 1, 1978·Annual Review of Pharmacology and Toxicology·G A Johnston
Sep 27, 1979·Nature·B E Alger, R A Nicoll
Jun 1, 1977·Canadian Journal of Physiology and Pharmacology·K KrnjevićR Werman
Mar 1, 1985·Journal of Neuroscience Methods·F R MoralesM H Chase
Jun 1, 1974·The Journal of Physiology·J N Barrett, W E Crill
Jun 29, 1971·Experimental Brain Research·D R CurtisG A Johnston
Mar 1, 1960·The Journal of Physiology·D R CURTISJ C WATKINS

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Citations

Dec 8, 2009·Experimental Neurology·Jack YamuyMichael H Chase
Nov 9, 2000·Journal of Neurophysiology·P A Núñez-AbadesW E Cameron
Apr 4, 2000·Physiological Reviews·J C ReklingJ L Feldman
Oct 17, 2002·Journal of Applied Physiology·Janna L MorrisonRichard L Horner

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