PMID: 7086435Aug 1, 1982Paper

Studied on cerebellar haem metabolism in the rat in vivo

Journal of Neurochemistry
F De Matteis, D E Ray

Abstract

Rats were injected intraventricularly with 5-amino[4-14C]laevulinate and the radioactivity recovered in the total cerebellum homogenate and in its haem and porphyrin fractions was determined in time. Two phases could be distinguished in the decline of haem radioactivity, suggesting labelling of at least two pools of widely different turnover rates. Succinyl acetone, when injected intraventricularly, caused a marked and long-lasting inhibition of cerebellar 5-aminolaevulinate dehydratase activity and a corresponding inhibition of the incorporation of [14C]5-aminolaevulinate into cerebellar haem in vivo. Inhibition of cerebellar haem biosynthesis by succinylacetone was followed by stimulation of the first enzyme of the pathway, 5-aminolaevulinate synthase, whereas intraventricular injection of haematin led to a significant depression of the activity of the enzyme. This suggested that the cerebellar 5-aminolaevulinate synthetase is regulated by haem through a negative feedback mechanism. Rats given repeated doses of succinylacetone, so as to maintain 80% inhibition of their cerebellar 5-aminolaevulinate dehydratase activity for 5 days, failed to exhibit any obvious symptoms of toxicity but became more sensitive to the neurotoxic e...Continue Reading

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·B LindbladG Steen
Dec 1, 1979·Journal of Neurochemistry·V A Percy, B C Shanley
Jul 1, 1978·Archives of Biochemistry and Biophysics·J R PaternitiD S Beattie
Dec 1, 1978·Experimental Neurology·C A Pierach, P S Edwards
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R TenhunenR Schmid
Sep 1, 1970·The Biochemical Journal·B AschenbrennerM Rabinowitz
Jan 1, 1969·Journal of Applied Physiology·C A GoodrichJ R Pappenheimer
Jun 1, 1980·Biochemical Pharmacology·V A Percy, B C Shanley
Jun 15, 1981·The Biochemical Journal·F De MatteisL Wetterberg
Dec 1, 1955·The Biochemical Journal·K D GIBSONJ J SCOTT

Related Concepts

Succinylacetone
Aminolevulinic Acid Hydrochloride
Porphobilinogen Synthase
5-Aminolevulinate synthase
Cerebellum
Feedback - System Communication
Heme
Heptanoates
Porphyrins
August Rats

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