PMID: 8968459Dec 1, 1996Paper

Studies evaluating high-dose acyclovir, intravenous immune globulin, and cytomegalovirus hyperimmunoglobulin for prophylaxis against cytomegalovirus in kidney transplant recipients

The Annals of Pharmacotherapy
B I DickinsonM Gosland

Abstract

To describe the epidemiology and pathogenesis of cytomegalovirus (CMV) and critically analyze the studies evaluating the cost, safety, and efficacy of high-dose acyclovir, intravenous immune globulin (IVIG), and CMV hyperimmunoglobulin (CMVIG) for prophylaxis against CMV in kidney transplant recipients. Appropriate articles were identified by searching MEDLINE. Various combinations of the following medical subject heading terms were used: immunoglobulins, intravenous; acyclovir; CMVIG; CMV infections; kidney transplantation; IVIG; and prophylaxis. Studies evaluating or discussing the cost, safety, and efficacy of IVIG, high-dose acyclovir, and CMVIG in kidney transplant recipients were included. The data were evaluated with respect to study design, patient population, prophylactic regimen, incidence of CMV complications, investigators' definitions of terminology, and cost analysis. The studies are summarized in tables and discussed in the text. The definitions of terminology used by the investigators varied widely among studies. The studies were reviewed and discussed using the following definitions: CMV infection was the presence of CMV antibodies in a previously CMV-seronegative patient or a fourfold rise in antibody titer af...Continue Reading

Citations

Oct 28, 1998·Scandinavian Journal of Infectious Diseases·S A BirkelandB Gahrn-Hansen
Mar 2, 2013·The Cochrane Database of Systematic Reviews·Daniel S OwersElisabeth M Hodson
Mar 2, 2013·The Cochrane Database of Systematic Reviews·Elisabeth M HodsonJonathan C Craig
Jul 19, 2002·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M M Addo, E S Rosenberg
Mar 23, 2001·Reviews in Medical Virology·G D Hart, C V Paya
Jan 13, 2021·Microorganisms·Carlo PerriconeRoberto Perricone
Apr 23, 2020·Journal of Autoimmunity·Carlo PerriconeRoberto Gerli
Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bryan N BeckerJohn D Pirsch
Oct 21, 1998·Infectious Disease Clinics of North America·B A Collin, R Ramphal

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