PMID: 1202902Jan 1, 1975Paper

Studies in cholestasis of pregnancy. V. Gallbladder disease, liver function tests, serum lipids and fatty acid composition of serum lecithin in the non-pregnant state

Acta Obstetricia Et Gynecologica Scandinavica
G SamsioeA Gustafson

Abstract

Women from an earlier series of cholestasis of pregnancy (CP) were called for a retrospective study to consider presence of gallstones in the gallbladder (evaluated by cholecystography), liver function tests, serum lipids and lipoproteins and the relative fatty acid composition of serum lecithin (as determined by GLC). The attendance in the retrospective study was 60%. Estimated on the total series (assuming that none of the non-responders would have a positive X-ray), the incidence of gallbladder disease was 23.7%. Among women with previous cholestasis of pregnancy and with a positive X-ray finding no characteristic changes in liver function tests or serum lipids were revealed. The women with positive X-ray had, however, a lower alpha-lipoprotein cholesterol than women with negative X-ray. A characteristic finding among women with positive X-ray was furthermore the low relative content of palmitic acid (16:0) in serum lecithin. Also women with negative X-ray had a lower relative content of palmitic acid than controls. It is suggested that the low palmitic acid content is expressive of an influence on liver lecithin synthesis pathways and that the serum lecithin fatty acid composition reflects similar changes in bile lecithin. ...Continue Reading

Citations

Jul 1, 1981·Gut·M M Steven
Mar 1, 1987·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A Järnfelt-SamsioeG Samsioe
Oct 1, 1980·European Journal of Clinical Investigation·J G KralA Gustafson
Oct 1, 1996·American Journal of Obstetrics and Gynecology·O M AlsulymanT M Goodwin
Jun 1, 1986·Histopathology·D B Rolfes, K G Ishak
Jan 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H Reyes

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