Studies in neuronal ceroid-lipofuscinosis: heterogeneous nature of neuronal autofluorescent lipopigments

Journal of Neuroscience Research
H S GargS K Srivastava

Abstract

A method has been developed for the complete extraction and fractionation of the autofluorescent lipopigments present in the neuronal tissue of Batten-Spielmeyer-Vogt (BSV) patient and normal subject, respectively. The fluorescent lipopigments that were about three-fold higher in BSV patient's brain as compared with normal subjects were separated into at least 7 fluorometrically and chromatographically distinct fractions by thin layer chromatography (TLC). Although the fluorescent lipopigments of the brain tissue of BSV patient and normal subject showed identical pattern of separation on TLC, the flourescence spectra of the individual lipopigment fractions from BSV patient was different from those of the corresponding fractions from the normal subject. The ultraviolet spectral studies with individual fluorescent lipopigment fractions indicated the presence of highly unsaturated conjugated chromophore.

References

Jan 1, 1975·Virchows Archiv. A, Pathological Anatomy and Histology·M EllederR Kohn
Apr 1, 1973·Lipids·W R Bidlack, A L Tappel
Mar 1, 1973·Analytical Biochemistry·B L FletcherA L Tappel
Feb 1, 1974·Archives of Neurology·D ArmstrongD E VanWormer
Jan 1, 1974·Journal of Neuropathology and Experimental Neurology·W Zeman
Aug 1, 1964·Experimental and Molecular Pathology·S BJOERKERUD
Aug 1, 1965·The American Journal of Medicine·L SCHNECKB W VOLK

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Citations

Jul 15, 1992·Mechanisms of Ageing and Development·D ArmstrongM Elleder
Jan 1, 1985·Folia Psychiatrica Et Neurologica Japonica·Y KurokawaN Kimura
Jan 1, 1988·American Journal of Medical Genetics. Supplement·M L KatzN Koppang
Jan 1, 1988·American Journal of Medical Genetics. Supplement·Y EtoA Okuno
Jan 1, 1988·American Journal of Medical Genetics. Supplement·L Black, R K Pullarkat
Jan 1, 1987·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·E I TraboulsiZ C de la Cruz

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Batten Disease

Batten Disease is a group of nervous system disorders known as neuronal ceroid lipofuscinosis. This feed focuses on neurobiological and neuropathological aspects of this disease.