Studies into the anxiolytic actions of agomelatine in social isolation reared rats: Role of corticosterone and sex

Journal of Psychopharmacology
Wilmie RegenassBrian H Harvey

Abstract

Anxiety disorders are severely disabling, while current pharmacological treatments are complicated by delayed onset, low remission rates and side-effects. Sex is also noted to contribute towards illness severity and treatment response. Agomelatine is a melatonin (MT1/MT2) agonist and serotonin (5-HT2C) antagonist purported to be anxiolytic in clinical and some pre-clinical studies. We undertook a detailed analysis of agomelatine's anxiolytic activity in a neurodevelopmental model of anxiety, the social isolation reared rat. Rats received sub-chronic treatment with vehicle or agomelatine (40 mg/kg per day intraperitoneally at 16:00 h for 16 days), with behaviour analysed in the open field test, social interaction test and elevated plus maze. The contribution of corticosterone and sex was also studied. Social isolation rearing increased locomotor activity and reduced social interaction in the social interaction test, and was anxiogenic in the elevated plus maze in males and females. Agomelatine reversed these behaviours. Male and female social isolation reared rats developed anxiety-like behaviours to a similar degree, although response to agomelatine was superior in male rats. Social isolation rearing decreased plasma corticoste...Continue Reading

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Citations

Jun 23, 2020·Expert Opinion on Drug Discovery·George KonstantakopoulosPanayiota G Michalopoulou
Dec 13, 2019·Pharmacological Reviews·Henry SzechtmanKurt Leroy Hoffman
May 19, 2020·Depression and Anxiety·A Irem SonmezPaul E Croarkin
Jan 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Esmé Jansen van VurenBrian H Harvey
Jul 20, 2021·Addiction Biology·Andre U DeutschmannLisa A Briand
Jul 27, 2021·Journal of Psychopharmacology·David M ThomsonBrian J Morris

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