PMID: 6408329Jun 27, 1983Paper

Studies of anterior pituitary-grafted rats: I. Abnormal prolactin response to thyrotropin releasing hormone, clonidine, insulin, and fasting

Life Sciences
R A Adler, H W Sokol

Abstract

Although the rat implanted with extra anterior pituitary glands (AP) under the kidney capsule has been widely used as a model of chronic hyperprolactinemia, its hormonal status has not been fully characterized. Using conscious, unrestrained female pituitary-grafted rats and sham-operated littermates, we investigated prolactin (PRL) secretion in response to the following stimuli: thyrotropin releasing hormone (TRH), clonidine, insulin, and fasting. The AP-implanted rats had a greater and more sustained rise in serum PRL after TRH than control rats, reflecting a direct effect of TRH on the ectopic lactotropes. In contrast after clonidine, which acts via the hypothalamus, the serum PRL rose to much higher levels in sham-operated rats than in rats bearing ectopic pituitary tissue. Both insulin-induced hypoglycemia and fasting decreased serum PRL in control rats, but the AP-implanted animals manifested a rise in serum PRL in response to these stimuli. Thus, the AP-implanted rat is not only a valid model of excess and abnormal PRL secretion, but it may also be useful for distinguishing between stimuli requiring an intact hypothalamic-pituitary unit and agents which act directly on the pituitary gland.

Citations

Mar 25, 2011·Neuroimmunomodulation·Julieta E Ochoa-AmayaMaria I R Carvalho-Freitas
Nov 14, 1998·The American Journal of Physiology·C C LuP S Wang
Feb 19, 1999·Metabolism: Clinical and Experimental·C C LuP S Wang

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