PMID: 1211859Dec 1, 1975Paper

Studies of catecholamines in amyloidosis

Annals of Clinical Research
O PenttiläE Alhava

Abstract

Amyloidosis was induced in 21 mice by daily injections of casein solution for four weeks. Thioflavine T staining showed that the induction of amyloidosis took place in all mice. The catecholamine (CA) content was estimated in the spleen, proximal colon and kidney. In spleen the noradrenaline (NA) content per wet weight of tissue in casein-induced amyloidosis was significantly (p less than 0.01) lower than in the controls but this reduction was not apparent because of the huge increase in the weight of amyloid spleens. In the proximal colon and kidney the NA content did not differ from the control values. By fluorescence histochemistry the adrenergic fibres appeared to be well maintained in the spleen, duodenum and proximal colon in casein-induced amyloidosis. The CA content of rectal mucosal biopsies from five patients suffering from amyloidosis was compared with that from seven control persons. There was no significant difference in NA content. The present results suggest that in amyloid disease detectable alterations in the CA content or such morphological changes in adrenergic nerve fibres, which can be detected by fluorescence histochemistry take place only in the most advanced disease, if at all.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.