Abstract
Interleukin-1 alpha and beta (IL-1 alpha and beta), tumour necrosis factors alpha and beta (TNF alpha and beta) and interferon gamma (IFN gamma) were tested for their chemotactic effects, their effects on chemotactic movement towards N-formyl-methionyl-leucyl-phenylalanine (FMLP) and their effects on random locomotion of human peripheral blood neutrophils through polycarbonate membranes in Boyden-type chambers. Both IL-1 alpha and beta, but no other cytokine tested were chemotactic for neutrophils using 'sparse-pore' polycarbonate membrane. Both TNFs, but no other cytokine, inhibited neutrophil chemotactic movement towards FMLP using the same membrane. No cytokine influenced random migration of neutrophils through polycarbonate membrane of standard pore density. These results suggest that IL-1 may have a role as a chemotactic mediator of inflammation, but that TNFs may inhibit chemotactic migration of neutrophils into inflammatory lesions.
Citations
Jun 17, 2000·Clinics in Dermatology·J M Schröder
Nov 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·V AasH B Benestad
May 11, 2006·Experimental Lung Research·Robert A CoxHal K Hawkins
Oct 17, 2001·Developmental and Comparative Immunology·N F NeumannM Belosevic
May 25, 2005·Veterinary Immunology and Immunopathology·Mhan-Pyo YangEui-Bae Jeung
Apr 21, 2004·Immunology·Terri N Ellis, Blaine L Beaman
Aug 1, 1993·Molecular Microbiology·W ShiD R Zusman
Mar 5, 2009·Medicinal Research Reviews·Velio BocciIacopo Zanardi
Jul 14, 2011·Reproduction in Domestic Animals = Zuchthygiene·R ZobelV Buić
Jul 16, 2020·Acta Cirúrgica Brasileira·Hasan Oğuz KapicibaşiSait Elmas
Oct 28, 2015·International Journal of Molecular Sciences·Kohei KurodaYoshiharu Okamoto
Jan 1, 1992·European Journal of Haematology·J ElsnerK Welte
Mar 20, 2018·Oncology Letters·Ling FuHongxue Cui
Oct 31, 2001·Clinical and Laboratory Haematology·M MargalitY Matzner
Mar 12, 2002·European Journal of Clinical Investigation·T C StamA M M Eggermont