PMID: 6965703Mar 1, 1980Paper

Studies of cloned Friend erythroleukemia tumor cells. Modulation of the tumor-specific cytologic T lymphocyte response by infectious Friend virus production in vitro

The Journal of Experimental Medicine
F PlataF Lilly

Abstract

The HFL/b tumor cell line, induced by Friend erythroleukemia virus in BALB.B mice, was used to study the relation between virus production or nonproduction and the antigens recognized by Friend virus-specific cytolytic T lymphocytes (CTL). Analysis of clones and subclones of these tumor cells revealed a high degree of heterogeneity with respect to the production and release into culture fluids of infectious Friend virus in vitro, ranging from high levels to low or undetectable levels of virus production. Although no major differences could be detected among the antibody-defined serotypes of the various clones, the susceptibility of cells of individual HFL/b clones to attack by Friend virus-specific CTL varied widely, and those clones which produced large amounts of infectious virus provided the most sensitive target cells. It was also apparent that production of infectious Friend virus was inhibitory to CTL generation in syngeneic mixed leukocyte-tumor cell cultures. Friend erythroleukemia virus-producing cells thus appeared to interact in a complex manner with the host CTL response by modulating their production of infectious Friend virus.

References

Jul 1, 1978·The Journal of Experimental Medicine·S GillisK A Smith
Jul 1, 1975·The Journal of Experimental Medicine·H A Freedman, F Lilly
Feb 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·I KamoH Friedman
Dec 1, 1970·Virology·W P RoweJ W Hartley
Jan 1, 1974·Scandinavian Journal of Immunology·G DorvalH Wigzell
Jul 15, 1973·International Journal of Cancer. Journal International Du Cancer·E M Scolnick, W P Parks

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Citations

Oct 28, 1986·Biochimica Et Biophysica Acta·M Zijlstra, C J Melief
Jul 1, 1986·The Journal of Experimental Medicine·C A HoltF Lilly
Sep 15, 1981·International Journal of Cancer. Journal International Du Cancer·J F SchneggS Carrel
Sep 15, 1981·International Journal of Cancer. Journal International Du Cancer·E GaraciE Bonmassar
Jul 1, 1986·European Journal of Immunology·A Schäfer, W Schmidt

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