PMID: 6977614Apr 1, 1982Paper

Studies of defective tolerance induction in NZB mice. Evidence for a marrow pre-T cell defect

The Journal of Experimental Medicine
C A LaskinA D Steinberg

Abstract

NZB mice manifest a defect in tolerance induction by deaggregated heterologous gamma globulins. We have used an adoptive transfer system to study the defect. Thymectomized, intact, or thymectomized recipients given thymic epithelial grafts were studied after lethal irradiation and reconstitution with NZB, DBA/2, or (NZB x DBA(F1 marrow depleted of mature T cells. NZB thymocytes were responsible for the tolerance defect of NZB mice. The information for the defect was present in the NZB marrow prethymocyte. That defect could only be expressed when there was further maturation in association with a thymus. However, the normal DBA/2 thymic epithelium served as well as the abnormal NZB thymic epithelium. These studies resolve existing conflicts as to whether the NZB marrow or thymus is responsible for the loss of tolerance in association with autoimmunity.

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Citations

Feb 1, 1990·Journal of Steroid Biochemistry·A H Schuurs, H A Verheul
Jul 6, 2001·Scandinavian Journal of Immunology·J D MountzH C Hsu
Dec 1, 1990·Immunological Reviews·A D SteinbergD M Klinman
Apr 1, 1995·Immunological Reviews·D M Klinman, A D Steinberg
Sep 1, 1990·The Journal of Clinical Investigation·A M Krieg, A D Steinberg
Jan 1, 1988·Autoimmunity·W E WinterN K Maclaren
Apr 1, 1992·Clinical Immunology and Immunopathology·A D Steinberg
Jun 1, 1983·Immunology Today·A CookeI M Roitt
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshiko HashimotoKenneth Dorshkind
Jul 1, 1982·Arthritis and Rheumatism·A D SteinbergR T Steinberg

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