Abstract
Twenty-two patients with Parkinson's disease (PD) were studied by clinical evaluation, assessments of dementia and depression, as well as electrophysiologic examinations for blink reflex (BR), cortical somatosensory evoked potentials (CSEP), brain stem, and long-latency auditory evoked potentials (BAEP, and LAEP), and cerebrospinal fluid (CSF) assays for monoamine metabolites. Results show that PD patients have a significant decrease of Mini-Mental State Examination (MMSE) scores (p < 0.05) and an increase of Hamilton Depression Scale (HDS) scores (p < 0.01), as well as a longer latencies of R2 in BR, N19 and P22 in CSEP, W4 and W5 in BAEP and P300 in LAEP (p < 0.01), and lower CSF levels of HVA and MHPG (p < 0.05). The findings suggest a correlation between dementia/depression and mesocorticolimbic and mesostriatocortic dysfunction with dopaminergic and noradrenergic deficiencies in PD patients. Furthermore, parkinsonian dementia parallels the length of duration of the disease, but not the severity of motor disability. Parkinsonian depression parallels both the length of duration of the disease and the severity of motor disability.
References
Sep 1, 1992·Annals of Neurology·M SchwarzJ Noth
May 1, 1992·Electroencephalography and Clinical Neurophysiology·B S GiesserL C Scheinberg
Jan 1, 1992·Schizophrenia Bulletin·S NiwaS Hayashida
Apr 1, 1992·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·R Neshige, H Lüders
May 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·S E StarksteinR G Robinson
Jul 1, 1992·The Journal of Cell Biology·D M RoofM D Rose
Jul 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·C A BigginsE G Spokes
Sep 1, 1991·Annals of Neurology·P GasparB Berger
Oct 1, 1990·Neurology·R MayeuxY Stern
Jan 1, 1990·The Journal of Nervous and Mental Disease·S E StarksteinR G Robinson
Jul 1, 1989·Annals of Neurology·J O RinneU K Rinne
Sep 1, 1989·Annals of Neurology·S M de la MonteJ H Growdon
Jan 5, 1985·Lancet·A J Lees
May 1, 1986·Journal of Affective Disorders·M MaesE Suy
Oct 1, 1985·Neurology·M J AminoffM L Rosenblum
May 1, 1988·Archives of Neurology·R M Torack, J C Morris
Apr 1, 1970·Journal of Neurology, Neurosurgery, and Psychiatry·R H Mindham
Dec 1, 1984·Lancet·R G Brown, C D Marsden
Jul 1, 1982·Electroencephalography and Clinical Neurophysiology·C C Wood, J R Wolpaw
Jul 1, 1984·Electroencephalography and Clinical Neurophysiology·S M Mason, D H Mellor
Nov 14, 1980·Science·E HalgrenP H Crandall
Jun 1, 1993·Synapse·E H LeeW R Lin
May 20, 1994·Science·V Y Bolshakov, S A Siegelbaum
Sep 1, 1993·Journal of Neurology·L G Chia, W C Shen
Jun 1, 1993·Journal of the Neurological Sciences·J HuttunenH W Lange
Jun 1, 1993·Journal of the Neurological Sciences·L G ChiaJ S Kuo
Citations
Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·J A Saint-Cyr, L L Trépanier
Nov 28, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Swen HesseOsama Sabri
Nov 1, 1996·Journal of the Neurological Sciences·O H ElwanM Fahmy
Mar 13, 2003·Neuropsychologia·J P HarrisM S Fowler
Sep 23, 2003·Parkinsonism & Related Disorders·A RojoS Quintana
Dec 3, 2009·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Monika NojszewskaKatarzyna Rowińska-Marcińska
Oct 16, 2010·Biomarkers in Medicine·Jakob NyhlénHenrik Zetterberg
Apr 15, 2000·The International Journal of Neuroscience·R P IaconoF H Nahab
Mar 23, 2006·Technology in Cancer Research & Treatment·Robert D PearlsteinPaul Haerich
Jan 26, 2005·The Pharmacogenomics Journal·F J BarreroJ García Yébenes
Mar 21, 2009·CNS Neuroscience & Therapeutics·Sarah JesseMarkus Otto
May 5, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Brit Mollenhauer, Claudia Trenkwalder
Jun 5, 2010·Brain Pathology·Min ShiJing Zhang
Sep 8, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Wei HanLiang Li
Apr 25, 2014·Arquivos de neuro-psiquiatria·Marcia da Silva LopesAna Caline Nóbrega
Feb 23, 2010·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Barbara Jasinska-MygaRyan J Uitti
Mar 9, 2018·Frontiers in Psychology·Bahar GüntekinErol Başar
Dec 1, 2009·Surgical Neurology·Jia-Wei LinLiang-Yo Yang