Studies of erythrocyte membrane loss produced by amphipathic drugs and in vitro storage

British Journal of Haematology
T J GREENWALTR E Williams

Abstract

Four amphipathic drugs, primaquine, propranolol, chlorpromazine and tetracaine, were used to cause endocytosis in glucose-depleted red cells, and the relative reduction of membrane surfaces was measured by the toluidine blue (TB) method. The TB measurements correlated well with the observed electron microscopic alterations. In vitro blood storage studies indicated loss of cell membrane during storage correlated with decreasing uptake of TB by the red cells. Regeneration of cellular ATP with adenosine did not always restore TB uptake by the cells. Loss of red blood cell membrane either by exocytosis or endocytosis may occur during normal in vivo or in vitro ageing, and may be increased in pathological states or by the action of drugs.

References

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Citations

May 30, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·T ConlonJ K Tomkins
Apr 1, 1984·The Journal of Cell Biology·A SaulC Kidson
Aug 1, 1978·British Journal of Haematology·T J Greenwalt, F O Lau
Jan 1, 1982·Scandinavian Journal of Haematology·A J NevilleR D Barr

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