PMID: 6160097Jul 1, 1980Paper

Studies of H-2Kb mutant mice. II. Definition of new H-2 specificities (H-2.68, 69, 71, 72) using the H-2Kb mutant, B6.C-H-2bm10

Immunogenetics
G M MorganR W Melvold

Abstract

Using the H-2Kb mutant strain, B6.C-H-2bm10, antibodies were produced which define four new H-2 specificities. This is in contrast to other H-2Kb mutant strains in which attempts to produce antibodies against the mutation have failed with the exception of H-2bm3 in which a new specificity, H-2.62, was described by absorption analysis of an H-2.33 antiserum. With the mutant strain as immunization donor in the combination (C57BL/10 x 129)F1 anti B6.C-H-2bm10, two new H-2 specificities, H-2.68 and H-2.69, were produced. H-2.68 is found only on B6.C-H-2bm10, while H-2.69 is present on B6.C-H-2bm10 and on all cells of the H-2k haplotype. By testing the appropriate H-2 recombinant strains, the reaction with the H-2k haplotype could be mapped to the H-2D locus, whereas in B6.C-H-2bm10 it must have occurred in the H-2Kb gene. The reciprocal immunization of congenic strains failed, but with B6.C-H-2bm10 anti-A.BY, the specificities H-2.71 and H-2.72 were produced: H-2.71 was present on cells of the b,d, and k haplotypes, while H-2.72 was found only on the b haplotype. Genetic mapping using H-2 recombinant strains showed the H-2.72 reaction to be associated with the H-2Kb, H-2Dd and H-2Kk genes. The specificities described were shown to ...Continue Reading

References

Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·P Lake, N A Mitchison
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J E ColiganS G Nathenson
Jan 1, 1978·Advances in Immunology·J Klein
Jan 1, 1978·Journal of Immunological Methods·C R Parish, I F McKenzie
Dec 1, 1978·Immunogenetics·H I KohnD C Shreffler

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Citations

Jan 1, 1987·Immunogenetics·D N MisraT J Gill
Jan 1, 1983·Immunogenetics·L R PeaseS G Nathenson
Feb 1, 1990·Journal of Immunogenetics·D N MisraT J Gill
Jan 1, 1981·Immunogenetics·C J MeliefR W Melvold

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