PMID: 6163044Sep 1, 1980Paper

Studies of human myelin proteins during old age

Mechanisms of Ageing and Development
H H Berlet, B Volk

Abstract

The electrophoretic protein patterns of myelin isolated from frontal and callosal white matter were studied in adult man up to the age of 90 years. The proportions of the four major myelin proteins remained virtually unchanged as did the total protein content of white matter and of purified myelin. The total mass of purified myelin that could be recovered from white matter gradually decreased with age, suggesting an age-related loss of myelin sheath and probably neurons as well, without detectable alterations of the regular protein composition of myelin. In most cases basic protein of myelin was preceded by one or two minor protein components on electrophoresis. One of them is tentatively identified as "prebasic" protein similar to the one previously observed in other species, because of its close electrophoretic apposition to the main basic protein. The second component was found less frequently and was thought to arise from specific types of proteolysis of myelin proteins. Prolonged time intervals between death and autopsy had little, if any, effect on the proportions of basic protein and proteolipid protein. Similar results were obtained when bovine brain was incubated under conditions designed to simulate post-mortem autoly...Continue Reading

References

Nov 1, 1975·Neurology·K A Ansari, J Loch
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·E BarbareseJ H Carson
Jun 1, 1978·Journal of Neurochemistry·C W ShultsJ G Wood
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·W CammerS Gordon
Nov 1, 1975·Journal of Neurochemistry·M B Lees, D S Chan
Jan 1, 1977·Brain Research Bulletin·J M MatthieuM L Joyet
Oct 1, 1973·Journal of Neurochemistry·W T Norton, S E Poduslo
Sep 1, 1972·Journal of Neurochemistry·H C AgrawalA L Prensky
Jun 1, 1977·Neurochemical Research·M A FishmanH C Agrawal

❮ Previous
Next ❯

Citations

Jan 1, 1988·Molecular Neurobiology·A T Campagnoni, W B Macklin
Dec 23, 2003·Neuroscience Research·Deng-Shun WangDennis W Dickson
Feb 19, 2003·Forensic Science International : Synergy·Susey KangDanton H O'Day
Jan 24, 2012·Neurobiology of Disease·Petr DusekWeidong Le
May 1, 1985·Journal of Neurochemistry·T F Cruz, M A Moscarello
Jun 16, 2018·PloS One·Jack R FoucherPaulo L de Sousa
Jan 1, 1990·Acta Oto-laryngologica. Supplementum·A MartiniV Magnavita
Sep 16, 1985·Klinische Wochenschrift·H G Rennke
Jan 1, 1981·The International Journal of Neuroscience·S W Harkins
Apr 21, 2007·Neurochemical Research·Jason D Hinman, Carmela R Abraham
Jul 28, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Hanwen LiuCornelia Laule
Jul 11, 2020·Cellular and Molecular Life Sciences : CMLS·Inge L WerkmanWia Baron

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.