PMID: 2433813Feb 1, 1987Paper

Studies of immune function of CD-1 mice exposed to aflatoxin B1

Toxicology
R V ReddyR P Sharma

Abstract

The immunotoxic potential of aflatoxin B1 (AFB1), a secondary metabolite of Aspergillus flavus and a known animal hepatocarcinogen, was evaluated in CD-1 mice. Male mice received 0, 0.03, 0.145 or 0.70 mg/kg of AFB1 orally every other day for 2 weeks in a corn oil:ethanol vehicle. Splenic lymphocytes were cultured in the presence of lipopolysaccharide (LPS), phytohemagglutinin (PHA), or pokeweed mitogen (PWM). A dose-related inhibition of [3H]thymidine uptake in lymphocyte cultures, with or without the above mitogens, was observed after 2 weeks of AFB1 exposure. Synthesis of DNA was decreased in mixed lymphocyte cultures. Primary antibody production by splenic cells, from animals challenged with a T-dependent antigen (sheep red blood cells), was affected by AFB1. No effects were observed, however, when animals were challenged with a T-independent antigen (LPS). A dose-related suppression of a delayed-type hypersensitivity reaction to keyhole limpet hemocyanin was observed. The results suggested that AFB1 was immunotoxic in CD-1 mice.

References

May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J M EssigmannG N Wogan
May 31, 1979·Annals of the New York Academy of Sciences·R P Sharma, P J Gehring
May 1, 1973·Poultry Science·G Y MichaelP B Hamilton
Mar 1, 1974·Poultry Science·J P ThaxtonP B Hamilton
Jan 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·J R ThurstonC K Graham
Sep 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·H SavelT Cardella
Jun 30, 1983·Toxicology and Applied Pharmacology·S C FriendH B Schiefer
Mar 1, 1980·Applied and Environmental Microbiology·C F Chang, P B Hamilton
Oct 2, 2009·Toxicology and Industrial Health·Robert W Coppock, Barry J Jacobsen

Citations

Aug 1, 1990·Journal of Applied Toxicology : JAT·S RaisuddinP K Ray
Dec 1, 1993·Mycopathologia·S RaisuddinP K Ray
Sep 1, 1991·Bulletin of Environmental Contamination and Toxicology·R J Verma, P J Raval
Jul 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·S J AllenB M Greenwood
Jan 1, 1991·Developmental and Comparative Immunology·T R ScottA B Bodine
Feb 1, 1995·Pharmacology & Therapeutics·M McLean, M F Dutton
Jan 1, 1989·Toxicology·R V Reddy, R P Sharma
Jan 1, 1991·Toxicology·V CukrováM Akao
Jul 20, 1999·International Journal of Immunopharmacology·E Y MoonS Pyo
Feb 24, 2000·International Journal of Immunopharmacology·E Y Moon, S Pyo
Mar 30, 1999·Research in Microbiology·F RossanoM R Catania
Aug 13, 2008·Clinical & Developmental Immunology·Yi JiangJonathan H Williams
Sep 12, 2015·Immunopharmacology and Immunotoxicology·Min JiangZhengqiang Yu
Mar 20, 2013·Journal of Applied Toxicology : JAT·Guoqing QianJia-Sheng Wang
Apr 28, 2005·Journal of Applied Toxicology : JAT·Mosaad A Abdel-Wahhab, S E Aly
Jul 5, 2015·Neurotoxicology·Fatima TrebakRabia Magoul
Aug 12, 2000·Fish & Shellfish Immunology·C A Ottinger, S L Kaattari
Apr 3, 2007·Toxicology Letters·Beate TammerRolf Altenburger
Jan 1, 1992·Critical Reviews in Food Science and Nutrition·D M Hinton
Oct 30, 2008·Journal of Immunotoxicology·Patrick J SabourinCarol L Sabourin
Mar 1, 1993·Journal of Dairy Science·R P Sharma
Jun 10, 2005·International Immunology·Yi JiangJonathan H Williams
Nov 9, 2004·The American Journal of Clinical Nutrition·Jonathan H WilliamsDeepak Aggarwal
Jul 1, 2020·Veterinary Medicine and Science·Victor Fei PangChih-Cheng Chang

Related Concepts

Related Feeds

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.