Studies of in situ-forming hydrogels by blending PLA-PEG-PLA copolymer with silk fibroin solution

Journal of Biomedical Materials Research. Part a
Tianyi ZhongBaoqi Zuo

Abstract

Hydrogels had been prepared by blending PLA-PEG-PLA copolymer with Bombyx mori silk fibroin (SF) solution. Copolymers were synthesized by ring opening polymerization of L-lactide in the presence of dihydroxyl PEG with molar mass of 400 and 1000, and characterized by using (1)H NMR and DSC. Hydrogels formed leaf-like lamellar structures with many nanoglobules which may reserve drugs or growth factors more effectively. Rheological measurements indicated that the adding of copolymer significantly accelerated the hydrogelation of silk fibroin solution which leads to orders-of-magnitude increase in the complex shear modulus to form rigid hydrogel. Hydrogelation kinetics could be controlled easily by changing the concentration ratio, kinds of copolymer and hydrogelation temperature, suggesting the hydrogels could be formed in situ under physiological conditions with suitable mechanical properties. Furthermore, Fourier transform infrared, X-ray diffraction, and differential thermal analysis were employed to study the structure of hydrogels. The copolymer and SF in blend hydrogels were phase separation. There was an increase of β-sheet content and formation of silk II structure during hydrogelation. These results may indicate that copo...Continue Reading

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Citations

Jul 19, 2013·Biomaterials·Nicholas A GuziewiczDavid L Kaplan
Nov 20, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Hatice Kaplan CanErdem C Uluışık
Dec 29, 2015·International Journal of Biological Macromolecules·Zhixia GengZugong Yu
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May 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Dakun MaYansong Wang
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Nov 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ge LiYouxin Li
Feb 18, 2021·Biomedical Materials·Maryam FarokhiHeinz Redl

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