PMID: 9429215Jan 1, 1997Paper

Studies of interleukin-12 in chronic hepatitis B virus infection

Journal of Viral Hepatitis
N V Naoumov, S Rossol

Abstract

Interleukin-12 is produced by antigen-presenting cells and regulates the balance between TH1/TH2 lymphocyte subsets, promoting cell-mediated immune reactions. Amongst patients with chronic hepatitis B undergoing interferon-alpha treatment, only those who clear hepatitis B virus show a substantial increase in the production of biologically active IL-12 and an inverse ratio between serum levels of IL-12p40 subunit and IL-12. The peak of serum IL-12 occurs after the hepatitis flare and precedes or coincides with the time of HBe seroconversion. These data indicate that IL-12 is an important element for establishing the host immune control on hepatitis B virus replication in patients with chronic hepatitis B virus infection.

References

Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G MarinosR Williams
Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F V Chisari
Jan 1, 1995·Annual Review of Immunology·F V Chisari, C Ferrari
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·D R MilichJ E Jones
Jan 28, 1994·Cell·W E Paul, R A Seder
Nov 1, 1993·Gastroenterology·J AisenbergL Mayer
Jul 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K TanakaM Masumura
Oct 1, 1993·Gastroenterology·T MaruyamaD R Milich
Jun 1, 1993·The Journal of Clinical Investigation·T MaruyamaD R Milich
Jan 1, 1996·The Journal of Experimental Medicine·X MaG Trinchieri
Sep 1, 1996·The Journal of Clinical Investigation·A PennaC Ferrari
Jan 15, 1997·The Journal of Clinical Investigation·D H LibratyR L Modlin
Apr 1, 1997·Journal of Virology·V J CavanaughF V Chisari
Jun 15, 1997·The Journal of Clinical Investigation·S RossolN V Naoumov
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G Dusheiko

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Citations

Feb 10, 2011·Journal of Clinical Immunology·Nirupma TrehanPatiShiv Kumar Sarin
Jan 27, 2009·Current Gastroenterology Reports·Anil Seetharam, Mauricio Lisker-Melman
Apr 2, 2003·Journal of Immunological Methods·Sergey V SennikovVladimir A Kozlov
Aug 17, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G PiazzollaS Antonaci
Dec 13, 2005·The Tohoku Journal of Experimental Medicine·Sami OzturkUgur Bozlar
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eirini I RigopoulouNikolai V Naoumov
Apr 1, 2008·Alimentary Pharmacology & Therapeutics·M Kumar, S K Sarin
Dec 12, 2012·Microbiological Research·Hemanta MukherjeeDebprasad Chattopadhyay
Nov 22, 2005·The Korean Journal of Internal Medicine·Youngil I KohSeung-Gyu Ji

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