PMID: 1193421Sep 1, 1975Paper

Studies of intestinal lymphoid tissue. I. Electron microscopic evidence of 'blast transformation' in epithelial lymphocytes of mouse small intestinal mucosa

Gut
M N Marsh

Abstract

The morphology of epithelial lymphocytes in osmium-fixed, Epon-embedded jejunum of adult mice was studied by light and electron microscopy. Toluidine blue-stained 1 mum 'thick' plastic sections were compared with adjacent thin sections, thereby permitting precise ultrastructural identification and description of selected epithelial lymphocytes. Their size and appearances varied considerably, ranging from typical small lymphocytes through medium-sized lymphocytes to large immunoblasts. A high proportion of medium-sized epithelial lymphocytes (mean diameter 6-9 +/- 1-1 mum) contained several lysosomes, extensive Golgi complexes, prominent centrioles and abundant ribosomes. Their appearances, therefore, corresponded directly to mitogen-stimulated lymphocytes. In contrast, immunoblasts were big cells (mean diameter 11-0 +/- 0-8 mum) with large, euchromatic nuclei and prominent nucleoli. The majority had pale-staining, ribosome-studded cytoplasm and thus resembled type I, or T blasts. Very rarely, densely staining blasts containing ribosomes and well developed rough endoplasmic reticulum were observed; these corresponded to type II or B blasts. These observations indicate that transformation of lymphocytes occurs within the interepi...Continue Reading

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Citations

Jul 1, 1987·Baillière's Clinical Gastroenterology·J Spencer, P G Isaacson
Aug 1, 1995·Scandinavian Journal of Immunology·G Boll, J Reimann
May 1, 1976·Gut·D P O'DonoghueP J Kumar
Aug 1, 1988·Gut·P BrandtzaegT O Rognum
Oct 1, 1991·The Veterinary Quarterly·E van GarderenT S van den Ingh
Oct 31, 2001·Nature Immunology·A HaydayJ Shires
Jan 1, 1994·International Reviews of Immunology·K FujihashiH Kiyono
Jan 1, 1979·Scandinavian Journal of Gastroenterology·M GuixR Whitehead
Feb 1, 1985·The Anatomical Record·K Kaneda, K Wake
Jul 14, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D A L HoffJ G Hatlebakk
Jan 1, 1990·Springer Seminars in Immunopathology·A M Mowat
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·M N MarshD B Gordon
Apr 21, 2018·Mucosal Immunology·Toufic Mayassi, Bana Jabri

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