PMID: 1193422Sep 1, 1975Paper

Studies of intestinal lymphoid tissue. II. Aspects of proliferation and migration of epithelial lymphocytes in the small intestine of mice

Gut
M N Marsh

Abstract

Mice were given either intraperitoneal tritiated thymidine (3H-Tdr) or colchicine to study proliferation and migration of intestinal epithelial lymphocytes. Both labelled medium and large lymphocytes ('immunoblasts') were observed throughout the epithelium, crossing the basement membrane and within villous lymphatics for at least seven days after 3H-Tdr administration. Epithelial lymphocytes are predominantly young cells, actively dividing at the rate of 1% per hour. They do not migrate along the villi, unlike epithelial cells, but circulate rapidly through the epithelium, returning to the lamina propria at the rate of approximately 3 epithelial lymphocytes/1000 epithelial cell nuclei/hour. The labelling pattern of epithelial lymphocytes and intralymphatic cells with time was very similar suggesting that epithelial lymphocytes therefore may directly enter adjacent lymphatics and hence gain access to thoracic duct lymph.

References

Dec 1, 1969·The Journal of Experimental Medicine·C GriscelliR T McCluskey
Jun 1, 1974·European Journal of Immunology·D Guy-GrandP Vassalli
Feb 1, 1971·Journal of Ultrastructure Research·P G Toner, A Ferguson
Jan 1, 1968·International Review of Cytology·P G Toner
Jul 1, 1971·The Journal of Experimental Medicine·S W Craig, J J Cebra
Apr 18, 1970·Nature·J G Hall, M E Smith
Sep 1, 1970·The American Journal of Anatomy·R F HagemannS Lesher
Jul 1, 1971·The American Journal of Anatomy·M N Ferreira, C P Leblond
Jan 1, 1968·Experimental Cell Research·K E Fichtelius
May 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·K E FichteliusR A Good
Mar 1, 1969·The American Journal of Anatomy·J Merzel, C P Leblond
Jun 1, 1966·Canadian Journal of Biochemistry·A D Perris
Jan 1, 1962·Acta Haematologica·R W CAFFREYN B EVERETT
Aug 1, 1961·Journal of Ultrastructure Research·B F TRUMPE P BENDITT
Jan 14, 1964·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J L GOWANS, E J KNIGHT
Apr 30, 1921·The Journal of Experimental Medicine·C H Bunting, J Huston

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Citations

Oct 31, 2001·Nature Immunology·A HaydayJ Shires
Oct 1, 1994·The Journal of Experimental Medicine·P Poussier, M Julius
Aug 1, 1988·Gut·P BrandtzaegT O Rognum
Aug 1, 1990·Gut·J VineyJ Spencer
Jun 1, 1996·The Journal of Allergy and Clinical Immunology·T W KnutsonL Knutson
Jun 10, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Madeleine D HuKaren L Edelblum
Mar 1, 1983·The Australian and New Zealand Journal of Psychiatry·R Fisher, C Harper
Jan 1, 1990·Springer Seminars in Immunopathology·A M Mowat
Aug 28, 2020·Immunological Reviews·Matthew A FischerKaren L Edelblum
Jan 1, 1993·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·H ScottP Brandtzaeg
Oct 1, 1986·Journal of Morphology·Robert J Temkin, Donald B McMillan
Dec 3, 2020·The Journal of Trauma and Acute Care Surgery·Martin MauserFrank Plani

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