PMID: 6408008Mar 1, 1983Paper

Studies of lung infections caused by Pseudomonas aeruginosa in mice treated with cyclophosphamide

Infection
P Mayer, H Walzl

Abstract

An experimental Pseudomonas aeruginosa lung infection was induced by aerosol exposure in mice which had been pretreated with cyclophosphamide. A single dose of 200 mg/kg cyclophosphamide resulted in leukopenia which lasted for three days. At the lowest PMN levels, the mice were exposed to aerosols containing varying doses of bacteria. The survival time of the mice and the number of viable bacteria in their lungs were determined. A dramatic rise in the viable counts of Pseudomonas organisms was found between 18 and 24 hours after infection. Mice which had not been pretreated with cyclophosphamide remained healthy and did not show any lung lesions. The number and phagocytic function of the alveolar macrophages remained unaltered after cyclophosphamide treatment. Thus, PMNs seem to play an important role in the lung's early defence mechanisms against Pseudomonas aeruginosa. This animal model could be of use in evaluating additional therapies for lung infections caused by Pseudomonas aeruginosa.

References

Oct 1, 1977·The American Review of Respiratory Disease·A K PierceG D Harris
Nov 1, 1978·The Journal of Experimental Medicine·L H BlockJ Drews
Jun 1, 1979·The Journal of Experimental Medicine·A B van oud Alblas, R van Furth
Jul 1, 1976·Infection and Immunity·C L PiersonI Feller
Aug 1, 1973·American Journal of Clinical Pathology·R C Brown, H C Hopps
Jul 1, 1973·The Journal of the Kansas Medical Society·M S Hirsch
Aug 1, 1973·The American Journal of Medicine·J E PenningtonP P Carbone
Apr 1, 1973·The American Journal of Medicine·R J AndersonT C Eickhoff
Jan 1, 1973·Archives of Internal Medicine·G M Green
Sep 1, 1974·The Journal of Clinical Investigation·E GoldsteinD Warshauer
Jan 1, 1964·The Journal of Experimental Medicine·G M GREEN, E H KASS

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Citations

Jan 1, 1994·Toxicon : Official Journal of the International Society on Toxinology·A L BaltchF Lutz
Nov 15, 1989·Veterinary Immunology and Immunopathology·P M BowlesM D Mutimer
Jul 1, 1992·International Journal of Food Microbiology·H Hof, J Rocourt
Jul 1, 1986·Diagnostic Microbiology and Infectious Disease·J D OliverK Linder
Jan 1, 1993·International Journal of Antimicrobial Agents·I A HolderA N Neely
Jun 1, 2001·Toxicon : Official Journal of the International Society on Toxinology·Y KomoriT Nikai
Jan 16, 2003·Trends in Microbiology·Richard S Stephens
Oct 1, 1986·Experimental and Molecular Pathology·J J CoalsonW G Johanson
Jan 4, 2006·Journal of Materials Science. Materials in Medicine·L HerschkeG Wegner
Mar 30, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jordi Moya-Laraño
Mar 1, 1993·Antimicrobial Agents and Chemotherapy·Y FukuokaH Narita
Nov 1, 1985·Infection and Immunity·D O SordelliA M Hooke

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