Studies of neurotrophin biology in the developing trigeminal system

Journal of Anatomy
A M Davies

Abstract

The accessibility of the primary sensory neurons of the trigeminal system at stages throughout their development in avian and mammalian embryos and the ease with which these neurons can be studied in vivo has facilitated investigation of several fundamental aspects of neurotrophin biology. Studies of the timing and sequence of action of neurotrophins and the expression of neurotrophins and their receptors in this well characterised neuronal system have led to a detailed understanding of the functions of neurotrophins in neuronal development. The concepts of neurotrophin independent survival, neurotrophin switching and neurotrophin cooperativity have largely arisen from work on the trigeminal system. Moreover, in vitro studies of trigeminal neurons provided some of the first evidence that the neurotrophin requirements of sensory neurons are related to sensory modality. The developing trigeminal system has been studied most extensively in mice and chickens, each of which has particular advantages for understanding different aspects of neurotrophin biology. In this review, I will outline these advantages and describe some of the main findings that have arisen from this work.

References

Oct 15, 1991·The Journal of Comparative Neurology·M FuscoA Leon
Oct 5, 1988·Neuroscience Letters·P DohertyF S Walsh
Jan 1, 1981·Developmental Neuroscience·A M DaviesG Burnstock
Oct 1, 1995·Developmental Biology·A M DaviesH Phillips
Oct 27, 1995·Science·H Thoenen
Jan 1, 1995·Annual Review of Neuroscience·M Bothwell
Nov 1, 1994·Journal of Neurobiology·A M Davies
Nov 1, 1994·Journal of Neurobiology·M Barbacid
Nov 1, 1994·Journal of Neurobiology·D R Kaplan, R M Stephens
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·D O Clary, L F Reichardt
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·G L Barrett, P F Bartlett
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·L Averbuch-HellerC Kalcheim

❮ Previous
Next ❯

Citations

Nov 24, 2001·Brain Research. Developmental Brain Research·A S Haeberle, R S Erzurumlu
Feb 5, 2009·Pediatric Research·Amitai Z KohnPrabha Kc
Mar 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Graziana GattoRüdiger Klein
Feb 16, 2006·Archives of Histology and Cytology·Yuko MaruyamaTakeyasu Maeda
Aug 16, 2011·Neurotoxicology and Teratology·Emel UlupinarKevser Erol
Oct 5, 2007·Brain Research Reviews·Nikolai E Lazarov
Dec 21, 2006·Neuroscience Letters·Yasushi IgarashiTakeyasu Maeda
Feb 3, 2004·The Journal of Comparative Neurology·Thomas E DillonM William Rochlin
Sep 11, 2002·Developmental Biology·Robert A Oakley, Beverly A Karpinski
Jun 29, 1999·Molecular and Cellular Neurosciences·A ForgieA M Davies
Oct 6, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·K FriedC Hildebrand
Dec 17, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·H A NorthM J Donoghue
Apr 22, 2003·Archives of Histology and Cytology·Bashar Anas AlkhamrahTakeyasu Maeda
Sep 18, 2001·The Journal of Comparative Neurology·P H Ozdinler, R S Erzurumlu
Apr 14, 2005·Journal of Neurobiology·Bariş GençReha S Erzurumlu
Oct 5, 2002·Journal of Neurophysiology·Arturas GrigaliunasCharlotte M Mistretta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.