PMID: 65371Mar 1, 1977Paper

Studies of perennial ragweed immunotherapy

The Journal of Allergy and Clinical Immunology
J S IronsC R Zeiss

Abstract

Perennial ragweed immunotherapy was studied in 24 patients with ragweed pollenosis. Cellular responsiveness was determined by measuring the cellular reactivity and sensitivity to ragweed antigen E (RW-AgE) by RW-AgE-induced leukocyte histamine release. Serum blocking antibody content was determined by measuring the serum RW-AgE binding capacity by ammonium sulfate coprecipitation of bound RW-AgE. Specific IgE (anti-RW-AgE) concentration was determined by polystyrene tube radioimmunoassay. Cellular responsiveness decreased with continuing immunotherapy, as did the specific IgE concentrations. The serum RW-AgE binding capacity, in contrast, increased as treatment continued. The absence of demonstrable correlations between RW-AgE binding capacity and cellular reactivity, cellular sensitivity, and specific IgE concentrations contrasted impressively with the demonstration of multiple significant correlations between the change in the RW-AgE binding capacity and the other parameters studied. The degree of increase in RW-AgE binding capacity correlated significantly with the degree of decrease in both the specific IgE concentration (p is less than 0.04) and the cellular sensitivity to RW-AgE (p is less than 0.003). these findings sugg...Continue Reading

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Citations

Jun 1, 1997·Allergy·A W Wheeler, K J Drachenberg
Dec 1, 1980·The Journal of Allergy and Clinical Immunology·S G HendrixA L Sheffer
Sep 1, 1984·The Journal of Allergy and Clinical Immunology·J L OhmanK M Leitermann
Aug 1, 1981·The Journal of Allergy and Clinical Immunology·S R HirschS H Cohen
Jun 1, 1988·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M BorisS Weindorf

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