PMID: 2506921Sep 1, 1989Paper

Studies of the carcinogenesis and tumorigenesis of skin applications of dodecylbenzene on hairless mice

British Journal of Industrial Medicine
O H Iversen

Abstract

Dodecylbenzene in various concentrations, dissolved in acetone to a final volume of 50 microliters, was applied twice a week for 78 weeks to the back skin of hairless mice, with or without pretreatment with 51.2 micrograms 9,10-dimethyl-1,2-benzanthracene (DMBA). A negative control group was painted with acetone only and a positive control group was given a single application of 51.2 micrograms DMBA. A few tumours developed but there was no significant skin tumorigenicity--that is, occurrence of benign or malignant tumours--by acetone alone, or by 16% dodecylbenzene. More tumours developed in the group treated with 80% dodecylbenzene than in the group treated with acetone alone or with 16% dodecylbenzene, but there was no significant difference between treatments with 16% and 80% dodecylbenzene. There was only a suggestive increase in tumorigenesis in the group given 51.2 micrograms DMBA and thereafter painted with 40% dodecylbenzene twice a week compared with the group given 51.2 micrograms DMBA once. As regards histologically malignant tumours--that is, carcinogenicity--the group treated twice a week with 16% dodecylbenzene alone developed two skin malignancies, whereas only one carcinoma was observed in the group treated wit...Continue Reading

References

Jan 1, 1978·Journal of Toxicology and Environmental Health·G R LankasR T Christian
Jan 1, 1985·Drug and Chemical Toxicology·H Van CauterenR Marsboom
Jan 1, 1982·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·O H Iversen
Jan 1, 1984·Cancer Investigation·O H Iversen, E G Astrup
Nov 1, 1962·Toxicology and Applied Pharmacology·U SAFFIOTTID L OPDYKE
Aug 1, 1949·Journal of the American Pharmaceutical Association·S S HOPPERV V COLE

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Citations

Jan 16, 2020·Critical Reviews in Toxicology·Ralph PirowAndreas Luch
Nov 21, 1992·Annals of the New York Academy of Sciences·B N Ames, M K Shigenaga

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