Studies of the development of brain barrier systems to lipid insoluble molecules in fetal sheep

The Journal of Physiology
K M DziegielewskaN R Saunders

Abstract

1. The development of the blood-brain and blood-c.s.f barriers to lipid insoluble substances of different molecular radii has been studied in fetal sheep, early (60 days) and late (125 days) in gestation, using labelled erythritol (C14), sucrose (3H or 14C), inulin (3H or 14C) and albumin (125I), or albumin and IgG detected by immunoassay. 2. Morphological studies of fetal brain and choroid plexus at the same gestational stages were carried out using thin section electron microscopy and the freeze fracture techniques. 3. Penetration of markers into c.s.f. was substantially greater at 60 days than at 125 days, but at both ages the steady-state level achieved appeared to be related to molecular size. 4. A simple model describing penetration from blood into c.s.f. at 60 days is proposed. It involves the assumption that c.s.f. and brain extracellular fluid are effectively separate compartments; morphological and permeability data which supports this assumption is presented. The data for c.s.f. at 60 days are consistent with the suggestion that the markers penetrate into c.s.f. by diffusion and are not restricted by small pores in the interface between blood and c.s.f. 5. The reduction in penetration which occurred by 125 days for a...Continue Reading

Citations

Dec 23, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I C MunroW O Bernt
Dec 1, 1994·Histochemistry·N R SaundersK M Dziegielewska
Apr 1, 1993·Journal of Neurocytology·K M DziegielewskaN R Saunders
May 14, 1993·Brain Research·R H Fabian, C E Hulsebosch
Jan 1, 1983·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D E PanruckerN R Saunders
Jan 1, 1989·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·K M DziegielewskaN R Saunders
Jan 1, 1982·Pharmacology & Therapeutics·B M Assael
Feb 1, 1985·Brain Research·G FossanN R Saunders
Jun 28, 2006·The European Journal of Neuroscience·P A JohanssonN R Saunders
May 1, 1986·Journal of Neurochemistry·A FuglsangA Gjedde
Jul 1, 1986·Neuropathology and Applied Neurobiology·K Møllgård, N R Saunders
Feb 3, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Margie Castillo-MelendezSuzanne L Miller
Jan 1, 2015·Seminars in Cell & Developmental Biology·Nellwyn Hagan, Ayal Ben-Zvi
Dec 27, 2011·Neurotoxicology·C Joakim EkNorman R Saunders
Mar 3, 2015·Frontiers in Neuroscience·Sophie WhishNorman R Saunders
Nov 13, 2014·Frontiers in Neuroscience·David BuenoJordi Garcia-Fernàndez
Jan 8, 2015·Frontiers in Neuroscience·Norman R SaundersHans-Christian Bauer
Mar 18, 1994·Brain Research. Developmental Brain Research·P A Stewart, K Hayakawa
Sep 1, 1987·The Journal of Surgical Research·K L SchmidtT A Miller
Mar 5, 1999·Clinical and Experimental Pharmacology & Physiology·N R SaundersK M Dziegielewska
May 19, 2018·The Journal of Physiology·Norman R SaundersMark D Habgood
Feb 23, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Pia A JohanssonNorman R Saunders
Apr 15, 1994·Microscopy Research and Technique·C L Farrell, W Risau
Jan 3, 2001·Microscopy Research and Technique·K M DziegielewskaN R Saunders
Jun 5, 1998·Clinical and Experimental Pharmacology & Physiology·M D HabgoodN R Saunders

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