PMID: 9179429May 1, 1997Paper

Studies of the effects of inhaled magnesium on airway reactivity to histamine and adenosine monophosphate in asthmatic subjects

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
J HillJ Britton

Abstract

Magnesium is a cation with smooth muscle relaxant and anti-inflammatory effects and may therefore have a role in the therapy of asthma. Several studies have investigated the effects of intravenous magnesium in acute or stable asthma, but little is known about the effects of inhaled magnesium. To measure the effects of a single inhaled nebulized dose of 180 mg magnesium sulphate on airway reactivity to a direct-acting bronchoconstrictor (histamine) and an indirect-acting bronchoconstrictor (adenosine monophosphate [AMP]) in asthmatic subjects. Two separate randomized, double-blind, placebo-controlled crossover studies, each involving 10 asthmatic subjects. In the histamine study, airway reactivity to histamine was measured and lung function allowed to recover spontaneously over 50 min before administering nebulized magnesium sulphate or saline placebo. Airway reactivity to histamine was then measured at 5 and 50 min. In the AMP study, a single measurement of airway reactivity was made 5 min after magnesium or placebo. In the histamine study, the provocative dose required to reduce FEV1 by 20% (PD20FEV1) was significantly lower after magnesium than after placebo, by a mean (95% CI) of 1.02 (0.22-1.82) doubling doses at 5 min (P =...Continue Reading

Citations

Jul 22, 2010·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Fedoua GandiaZouhair Tabka
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Colin PowellBrian H Rowe

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